E2=42 is enough to create a lot of major problems.
You had E2=7 or E2<7? If the latter, you don't know what it was.
Not enough info hear to suggest dosing. What exactly is your protocol?
Get E2 near 22pg/ml
Make sure that thyroid is OK, see the thyroid basics sticky and check body temperatures.
Once TT, FT, E2 are good and thyroid function is good and if you still feel depressed, you could try Wellbutrin, which does not have SSRI sides.
Read the advice for new guys sticky and see if anything there fits. Post all lab work and more info, age weight, waist, diet, medications, medical issues, mood, sleep patterns, stress ...