I thought I would open a new thread for this just to keep this simpler. I was wondering if anyone has had a similar experience to me as far as TRT and if anyone has found an explanation, solution, or any suggestions at all. My endocrinologist seems to be clueless as to why I still feel like junk with my current lab values…
Here’s where I’m currently sitting as far as labs:
Total T 650 ng/dL (taking 100mg/wk T cyp)
E2 22 pg/mL (taking 0.125mg/wk Anastrozole)
Cortisol 19.6 ug/dL
TSH 2.17 uIU/mL
Free T4 0.75 ng/dL (taking 50ug Levothyroxine/day)
I’ve been on TRT for 1.5 years now; original T level of 280 ng/dL. On 120mg/wk of T-cyp (split into 3 doses/wk), I felt not much better than before ever starting. I dropped on my own to 100mg/wk about 6 months ago and felt slightly better but still far from normal.
If I attempt to increase to even 110mg/wk T cyp (also increasing Anastrozole by 10%), I feel much worse: brain fog, terrible energy, low libido, depressed mood, lack of interest in things I normally enjoy, etc. 120mg/wk produces even more severe symptoms than a 110 dose, with E2 managed. Right now, I still feel pretty darn bad (all the symptoms I jsut mentioned) on 100mg/wk. I have still not come close to feeling “normal” again even after 1.5 yrs. of TRT. I really have no clue what else to try.
Has anyone had a similar experience? Is there a genetic limit for how much T the body can handle? Should I consider dropping my dose below 100? Any suggestions whatsoever?
Final None: I know the Free T4 is low. My doc has tried me at 75ug/day Levothyroxine for 8 weeks, bringing Free T4 to 1.25. However, he dropped me back to 50ug/day because on the 75/day dose, my TSH dropped to 0.09 (range 0.3-4.0 uIU/mL). For the record, I felt no different on the 75ug/day compared to the 50ug/day. On the 50ug/day, my body temp is consistently in the 98.4-98.6F range.
Thanks in advance,