T Nation

Feel Like Myself on Levothyroxine


Hey guys, so I don’t have hypothyroidism but when I took a couple of T4 pills, I felt SO much better. I’ve had pretty major depression, fatigue, and no sex drive for over two years. and when I popped a T4, boom, I felt like myself again. I’ll let you know that I’ve tried just about every antidepressant and none of them have worked for me. Now I’ve only taken levothyroxine once and I don’t plan on continuing to use it, but why does it make me feel so much better? Here are my thyroid levels for reference.

F T4,Free(Direct) 0.95 0.93-1.60 (ng/dL)
F Triiodothyronine (T3) 90 71-180 (ng/dL)
F TSH 1.240 0.450-4.500 (uIU/mL)


Your TSH should be under 1. so you’re a little high there. If you feel great, why stop?


This thread is one of many and I will not seek and read to know what has gone on earlier. We need context to do thing properly.

  • TSH should be nearer to 1.0

  • T3, T4, fT3, fT4 should be nearer to midrange and this appears to be your problem.

Please read the stickies found here: About the T Replacement Category

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc
  • thyroid basics <-- read this

Check oral body temperatures as per the thyroid basics sticky.

Your problem could be iodine deficiency if not using iodized salt.

Your experiment with T4 has diagnostic value and your perceived benefit should motivate you do get your thyroid function optimized.