Reverse T3 slams on the brakes metabolically and causes Free T3 to pool as both Free T3 and Reverse T3 compete for the same receptors and this would decrease SHBG since Free T3 speeds up the liver’s production of SHBG.
You have 3 different factors suppressing SHBG, insulin resistance, being overweight and high Reverse T3. Ipamorelin did nothing for me and my doctors believes it’s do to insulin resistance. The correct treatment for high Reverse T3 is T3 only treatment if unable to lower it <15 ng/dL naturally, T4 treatment in those with conversion problems will only see higher Reverse T3.
My SHBG has gone up slightly from 16->22 when making lifestyle changes and injecting smaller doses every 2 days versus moderate doses twice weekly. Large doses is the protocol best for high SHBG men, those large peaks lowers SHBG more effectively. You want the opposite and probably why SQ was recommended do to it’s more steady, slower release into the bloodstream.
You more than likely would do very well on more frequent injections, most low SHBG men do.