T Nation

Familial Hypercholesterolemia (High Cholesterol) and TRT

I’ve always taken care of myself. These photos are of me at 26/27 before I “started taking care of myself”.

I didn’t change the way I care for myself or my healthy lifestyle, I simply started taking more supplements geared towards lowering cholesterol.

I do not eat much sugar, I don’t touch soda, i don’t smoke or drink, i eat primarily whole grains, eggs, chicken and 99% fat free turkey, I eat broccoli and avocado daily. I do eat 3700-4000 calories a day. But primarily all healthy food.

I just have FH, nothing to do with my lifestyle. It’s a really shitty card to be dealt, given how well I do take care of myself.

I’d love to see any study showing 200 being a beneficial level, that would be awesome. However my advanced lipid numbers are still quite horrific.

You convinced me brother. Have you check out @dbossa YouTubes or FB pages? He might have info on what TRT could do for naturally high cholesterol.

1 Like

We actually talked a bit via email. I’m reaching out to a couple doctors he recommended to chat with them. Also seeing a lipid specialist in a few weeks.

I appreciate it man!

Ehhh, I’d argue it does… above 130 is considered borderline, above 160 is considered high and 190 is considered “he needs a statin”… whilst @aaronca isn’t at 190, he’s close and his particle size is off, his + HDL is low,

Also, anything above 200 is considered detrimental, below 200 is preferable… though if low cholesterol is because HDL cholesterol has been crushed then its not preferable. His apolipoprotein B is quite high (one of main proteins within LDL known to induce organ damage over time), involved within healthy metabolism of lipids…

TRT isn’t going to help him (or hurt him) if the dosage isn’t too high, whilst I’m all for hormonal optimisation, the truth is going high (say in the 1000’s) for most will knock HDL by 10-15%, this isn’t what Aaronca needs… if @aaronca wishes to use AAS or engage within hormonal “optimisation” it is of my unprofessional opinion that a statin is a must… @aaronca I don’t know if this is possible, but if you can be honest with you’re doctor regarding what you wish to do, I’m almost certain (If you’re doctor believes in harm minimisation rather than “just say no”) you’ll be put on cholesterol lowering meds.

I also take red yeast rice extract btw, I don’t have familial hypercholesterolemia, I asked my mother “what is it that my grandmas husband had”, it turns out there’s a genetic mutation (that I may or may not harbour) in which the receptors towards LDL cholesterol don’t function adequately, thus even normal/slightly elevated levels of LDL will induce accelerated rates of lipid perioxidation… chances are though given that it was also accelerated with elevated LDL that I don’t have it

My lipids aren’t great because I’m always on 200-250mg weekly (HDL of 40-45 LDL of 105-115)

Regarding hypercholesterolemia, there were initial studies in which AAS like oxandrolone were used too “lower total cholesterol”… this was before we realised the reason total numbers were being lowered was because HDL was being crushed lol

1 Like

These numbers seem quite low. But maybe things have changed since Ive gone down this path.

We are talking about LDL alone, not total cholesterol there

For total cholesterol, below 200 is preferable

1 Like

Thanks. That makes more sense.

It depends where 200mg weekly gets you, for some it gets them to 1500-2000+ ng/dl with equally high ft to boot, hence the slight depression in HDL levels

Interestingly according to literature this decrease (overall HDL, impact on subtractions/particle sizes unknown) isn’t particularly compounded as test doses go higher, as 600mg weekly only decreases HDL by around 25%

I can’t say we’ve ever done a video on cholesterol… Might be an idea!

Would love for you to do that, FH / Genetic high cholesterol in particular.

There are some studies showing that TRT for individuals with high cholesterol due to NON generic reasons, actually gets lowered on TRT. Partially due to healthier life styles, exercise, being better state of mind due to optimized test, but I believe there are also some other internal reasons that are at play, maybe @unreal24278 would know (I could be totally wrong on the last part).

There’s another active post here now with an individual whose numbers improved although still bad, however they are 27% BF if I’m not mistaken.

There’s almost nothing that I can find regarding true genetic high cholesterol, hyperlipidemia, familia Hypercholesterolemia with TRT. I’d love to hear what a few of the doctors on your show think.

There’s like… no data on TRT and familial hypercholesterolemia A’s the medical community as a whole is piss scared to trial androgens within conditions relating to lipid disorders (for good reason… it’s potentially lawsuit city)… parts of the medical community still believe test causes prostate cancer, whilst an increase in DHT may predispose one to prostate ailment as they get older if they already have genetic predisposition, it’s actually now documented that hypogonadal men who acquire prostate cancer tend to have more aggressive varieties, furthermore… the prostate isn’t malleable like skeletal muscle as in… androgens can induce upregulation of AR and induce the synthesis of new AR in skeletal muscle, the prostate appears to have a fixed net amount of AR one is born with, hence why we don’t see guys on megadosages acquiring prostate cancer at like a 100x rate compared to the general populace

Within normal individuals, TRT (and no… I’m not talking about hormonal “optimisation”, which while great, isn’t medically mandated trt wherein levels are brought to the bare minimum of what one just needs for adequate physical function, muscle mass maintenance, glucose control etc) may slightly decrease total cholesterol, decrease atherogenic sub fractions of LDL etc

However there are confounding variables at play… did trt allow the individual to become more motivated to exercise/eat better. As both have tremendous impact regarding limiting the arherogesis (indirect and direct mechanisms)… can go into it if you wish but it’s not all that interesting (has to do with metabolic adaptation, changes regarding lipid metabolism etc)… even then there’s a range, extreme, ultra endurance training probably isn’t all that good for you according to literature

That’s huge, as one motivated to spend the cash for TRT will more likely be motivated to eat better and exercise and get as much out of it as possible.