Exogenous IGF-1 Effects Mice

Well I saw this and thought it was pretty interesting looking. Can’t get a full text yet, but the abstract was ok. Seems like exogenous IGF-1 can do some good in the rodents. Wonder if homo sapien are the same way? … =P

The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis.
Trejo JL, Llorens-Martín MV, Torres-Alemán I.

Cajal Institute, CSIC, Doctor Arce 37, 28002 Madrid, Spain.

Knowledge about the effects of physical exercise on brain is accumulating although the mechanisms through which exercise exerts these actions remain largely unknown. A possible involvement of adult hippocampal neurogenesis (AHN) in the effects of exercise is debated while the physiological and pathological significance of AHN is under intense scrutiny. Recently, both neurogenesis-dependent and independent mechanisms have been shown to mediate the effects of physical exercise on spatial learning and anxiety-like behaviors. Taking advantage that the stimulating effects of exercise on AHN depend among others, on serum insulin-like growth factor I (IGF-I), we now examined whether the behavioral effects of running exercise are related to variations in hippocampal neurogenesis, by either increasing or decreasing it according to serum IGF-I levels. Mutant mice with low levels of serum IGF-I (LID mice) had reduced AHN together with impaired spatial learning. These deficits were not improved by running. However, administration of exogenous IGF-I ameliorated the cognitive deficit and restored AHN in LID mice. We also examined the effect of exercise in LID mice in the novelty-suppressed feeding test, a measure of anxiety-like behavior in laboratory animals. Normal mice, but not LID mice, showed reduced anxiety after exercise in this test. However, after exercise, LID mice did show improvement in the forced swim test, a measure of behavioral despair. Thus, many, but not all of the beneficial effects of exercise on brain function depend on circulating levels of IGF-I and are associated to increased hippocampal neurogenesis, including improved cognition and reduced anxiety.

What does this mean? IGF is like Xanax?

that’s interesting. i see someone else here likes the insulin proteins.

i wish all of the current clincal-type studies of IGF-1/2 would just hurry up and make themselves real fast so we can know everything about what it does. =)

i’d like to see a definitive study regarding how much daily use of proteins like insulin or IGF-1 causes lifespan to shorten, if they truly do at all. i have serious concerns as a t1 diabetic hehe…

I don’t want carpal tunnel syndrome and lucky for me I’ve never had this problem. Maybe its cause my doses were low? Do most people get that with IGF?