Symptoms: Fatigue, lack of sex drive, recurring edema (mainly in ankles, feet, but holding water everywhere), lack of motivation, muscle weakness, moodiness, depression. No anxiety, which seems to be a common symptom. Erections occur during the night, but are not strong.
Dosage changes from last lab test:
100mg -> 120mg/week Testosterone enanthate
1mg -> 0 mg/week Anastrozole
My latest labs from a week ago Thursday (I was able to get orders from another doctor, luckily).
Triglycerides 53 <150 mg/dL
TSH 1.99 0.40-4.50 mIU/L
T3, Reverse 36 H 11-32 ng/dL
T3 Uptake 30 22-35%
T4, Total 4.5 4.5-12.0 mcg/dL
Free T4 Index 1.4 1.4-3.8
Antibodies 12 <35 IU/mL
Total 805 250-1100 ng/dL
Free 169.9 46.0-224.0 pg/mL
Bioavailable 334.6 110.0-575.0 ng//dL
SHBG 22 10-50 nmol/L
Albumin, Serum 4.3 3.6-5.4 g/dL
Pregnenolone 16 13-208 ng/dL
CBC (more information available, below are just the “red flags”)
RBC 4.13 L 4.20-5.80 Million/uL
MCV 102.4 H 80.0-100.0 fL
MCH 34.3 H 27.0-33.0 pg
Progesterone <0.5 <1.4 ng/mL
Estradiol 35 <= 39 pg/mL
Progesterone is very low, suggesting my HCG dose should have been higher. Since I had these labs drawn a week ago, I had increased the dosage of HCG from ~120IU to 250IU since I planned on having blood work drawn again within a month anyway, I figured this would be a good experiment. Luckily, it seems that my experiment was a good idea, since it seems my progesterone has cratered, and raising the HCG should bring this back up.
Meanwhile, I have macrocystic anemia. I do not know what is causing this. I eat 4oz beef or chicken liver everyday along with 12oz of spinach, so I think I have B-12 and folate covered. I eat 220g of mostly animal protein per day, so I believe I have iron covered as well. Previous vitamin lab work showed no deficiencies in any of these micronutrients. Perhaps I have developed an absorption issue. This could also be related to the diarrhea I have suffered from in the past few weeks. I have since cut back on the capsaicin-containing spices and late-afternoon caffeine in an attempt to remedy this problem with some results.
Estrodiol is again off the mark only this time in the opposite direction. I have not taken more anastrozole, and my feet are swelling after subsiding for a week (although I am honestly not sure if my edema is related to E2 at all). I plan on going on a 1/8 mg/week regimen seeing as I seemed to over-respond to previous dosages.
I should note that the above labs were taken 2 days after a scheduled injection of testosterone enanthate (dosed 3x weekly). I purposefully avoided taking the shot in anticipation of the blood draw, so testosterone levels should be a bit below previous values.
I should have values for free and total T3 soon. I also took a DHEA-S test today since the fatigue I am experiencing is causing me some hardship, and I want more information sooner.
Continue on 120mg/week testosterone enanthate
Continue taking 250IU HCG 3x/week
Start 1/8mg anastrozole / week (any recommendations on how to dose this? I am not sure if I can split an 1/8th of a pill, so I might have to go 1/8 E7D). Changing two variables makes for a rather poor experiment, but I changed two variables last time I had blood drawn (+20% in testosterone enanthate and near-elimination of AI), so this would not be the first time I made a mistake.
I welcome any comments or suggestions, including what blood tests to get next. I have orders on hand for testosterone (total, free, bioavailable, SHBG, and albumin), estrogen panel (includes estradiol and estrone [doc gave me this without me asking]), progesterone, and pregnenolone, so I imagine I will get those in three weeks. I should be able to get more without any difficulty.
EDIT: I just discovered that pregnenolone is available OTC. I imagine if 250IU 3x/week doesn’t get my pregnenolone to 180 that this is something I should look into, yes?
EDIT 2: I am beginning to think most of my problems with fatigue, lack of sex drive and edema are related to the pregnenolone. I am basing this on the fact that my E2 is not far from where it ought to be and that most posts I read with guys with way higher E2 levels do not experience anywhere near the same level of symptoms I am experiencing. Meanwhile, my symptoms correspond to the lists of high pregnenolone symptoms that I’ve come across.