This forum is TRT and high normal youthful T levels are the goal. In that context, E2=22pgml is what it is.
If your E2 crashed on that dose, assume that you are an over-responder and follow the path suggested in three of the stickies.
When you get balance at the suggested levels, you are free to experiment and see if you feel better on different doses. Then you can get more labs and see what you numbers are then post your findings and conclusions about what works best for you.
I feel good at E2=22pg/ml and many others do. At E2=22pg/ml I did not feel a good.
Your well being is also controlled by your thyroid and adrenals. TRT can restore metabolic rates and the other systems might not be able to keep up. There is more going on than T. T is more effective when not opposed by E2. E2 controls SHBG and thus effects FT levels. SHBG+T is not bio-available. So reducing E2 can effectively increase the effects of T.
Your description really sounds like a typical E2 crash. You did not get E2 labs that day, but can find the lower dose that works then do lab work and make more dose adjustments then to get near E2=22pgml and see if life is better.
Ratio of E2 to TT is meaningless. E2:bio_T or E2:FT makes sense.