I've been on TRT for 2 1/2 years now and it's taken me the first 2 years to finally find my groove.
I know it's individualistic (one hat does not fit all) but with that said, I must agree with KSman, as in my case, that E2 in the low 20's is "ideal"
I've always injected 140mg weekly resulting in average T values of 750-950. It has only been in the last several months that I've finally broken this up into 2 weekly injections.
At first my doc had me on Anastrozole at 1 mg 3x weekly and I was fine until a few months later. My E2 had plummeted to 15 and I felt like shit. It had mitigated the positive effect of my increased T value.
My doc then took me off the Anastrozole completely and a short time thereafter started to feel positive results, however, it was short lived. After 6 months my E2 had risen to 50 and I felt awful again.
Anastrozole was then re-introduced, this time at .5mg 3x weekly, however i actually take .5 mg 2x weekly with injections and a few months later I felt great again with E2 level now at 25 and maintaining.
It may take you some time but keep making adjustments based on how you feel and working with your Doc.