I was getting severe elbow pains at .5 EOD, also irritabilty and low libido--similar to my state before TRT, actually. I thought .5 made sense because I was on 200mg of Test per week. I skipped 2 doses to let E2 recover and then went to .25 EOD, and haven't had to alter it since. Amazingly my doc prescribed it at 1mg per day. Glad I had already done some research and knew better!