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Erection Issues Low Estrogen

Hello all,

I have been trying to nail down my arimidex dosage for awhile now. My doctor originally had me at 2 pills a week. After doing some research i found that to be way too much also. I went to 1/2 a pill twice a week. Was starting to have week erections and would lose erections during sex. Couldn’t even keep it hard to put on a condom. Other issues were enlarged prostate like issues with urination. Frequent at night along with weak stream. I got my blood work and estrogen was bellow 5. I stopped arimidex all together for 10 days. Started to feel a little bloated and tenderness in nipple area. Erections were only slightly better. So decided to go to quarter pill twice a week. After I take the quarter the next day I have all kinds of erection issues again. Could that much cause that much of a drop? Too sensitive? Any thoughts? Feels like I am holding a fair amount of water still. Cholesterol was mildly high also.

Appreciate the help, any other info let me know. I have scoured the web for months on this.

37 years old
200Mg Test Cypionate week split every 3 days
230 pounds 5’11 25% body fat

You didn’t give us any E2 numbers.

More than likely, your e2 rebounded from stopping the arimidex, and that’s why you had those symptoms. Shouldn’t have taken another pill though.

Crushing your e2 like that will cause a whole host of issues, its not pretty. Getting sick, joint pain, fatigue.

Also, the frequent urination is a symptom of LOW E2!
200 a week is pretty high. but I don’t know what your numbers look like. Is it possible that you might be able to drop your test slightly and not use an AI at all?

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It sounds like you may be over estimating your water weight and underestimating the fat you carry.

I’d suggest switching to 50mg test twice per week and dropping your AI for a week. Get blood work done at that point. You may not need an AI with a reduced T dose and no AI may solve all your problems


Don’t you think he should wait a little longer to retest e2? I always give it a few weeks at least.

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200mg weekly is way too much for most, I didn’t even need an AI 50mg twice weekly. The problem is you’re guessing about where your E2 levels are and that always ends in disaster. Excess urination, feeling cold and achy joints is caused by low E2. You also want us to guess based on your dosage, weight and age. You might find at 50mg twice weekly that you don’t even need an AI.

Labs are the only way to get dosing correct, look where guessing has gotten you. Months of misery.

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Thanks guys for all the information. I truely appreciate it. How does this plan look:

Switch to two 50 mg test a week
Stop Arimidex for a couple weeks
Lose some lbs
Get blood work in a couple months?

E2 <5 was

Sounds perfect, it takes 6 weeks for your blood levels to balance out after a dosage change. That is when you run labs.

I remember intending to type a month not a week. Good catch. One week isn’t close to long enough.


Don’t mess with arimidex again until you have actual numbers of what your e2 is without it at 50mg twice a week. You don’t want to keep making that mistake, trust me.

If you start having high e2 symptoms while on, don’t panic. When I was adjusting my dose (50mg twice a week) and trying no AI, I had that urge to use something to control my e2. I felt slightly more emotional, nothing serious, had some minor forehead acne, no bloating and my dick was a little less responsive, harder to orgasm, nipples got slightly sensitive but it never progressed.

So I figured my e2 was in the “higher” range, but I didn’t mess with an AI, so that I could see what my levels were. They ended up being 32 on trough day, which isn’t that bad. I ended up just lowering my Test dose a little bit (now take 40mg twice a week instead of 50) and I am still battling with it a little, but I need to lose some weight as well. I would rather not use an AI, BUT if you need one, as in, having symptoms, there is no question as to whether you should use it. . But the big question is. DO YOU NEED IT?.

You have to find out first.

Most guys need some anastrozole. A few, not rare, are anastrozole over-responders who need 1/4th the amount that others need. Because you are struggling, you could try 1/4 mg anastrozole twice per week.

Your E2 without anastrozole would typically be of little value. While rarely some do not need anastrozole to get good libido and sexual performance, most do. Your valid, in reportable range, lab results can be used to calculate a dose to get near E2=22pg/ml.

Most need ~1mg anastrozole for every 100mg injected T ester.

T–>E2 rate is driven by FT or Bio-T levels and anastrozole needs to match T levels.

We need your labs with ranges:

Your body weight and fat levels can easily be affected by thyroid status and iodine intake.

Please read the stickies found here: About the T Replacement Category

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.



That’s the wrong E2 lab test designed for females, your E2 is even lower than reported! Your AI dose is overkill. Your body can’t handle that much T and its showing in your RBC, you seriously need to lower your T dose! Inject 50mg twice weekly and drop the AI for awhile, then retest 4-6 weeks (E2 sensitive test) and then you can make an informed decision.

E2 levels in children, postmenopausal women, and men are much lower than in women of reproductive age. The increased sensitivity and specificity that are achieved by LC/MS-MS are the more appropriate choice for these clinical situations than the electrochemiluminescence immunoassay (ECLIA) method. LC/MS-MS offers superior analytical sensitivity, specificity and a larger dynamic range than immunoassays.1

The clinical applications benefiting from highly sensitive E2 measurement include the assessment of congenital defects in sex steroid metabolism and disorders of puberty. This sensitive assay also has application in the evaluation of estrogen deficiency in men and menopausal women, fracture risk assessment in these populations, and increasingly, in therapeutic drug monitoring of low-dose female hormone replacement therapy or antiestrogen treatment.