These are the issues that I see, in no particular order.
With infrequent injections:
- one does not feel well with peaks and crashes with T crash into a pool of peaked estrogens
- the high T peaks seem to promote more E2 and more T+SHBG, lowering average FT
- labs are less useful as one’s levels are not static
- with changing FT/Bio_T, steady serum anastrozole levels cannot match changing FT/Bio_T levels and E2 is not managed well
With E3.5D, one can inject T and take 1/2 weekly anastrozole dose and rising and falling T and anastrozole levels will not be steady, but will somewhat rise and fall together. This seems to work well for some. Its a bit much to ask some guys to do an EOD routine.
If one is injected hCG, that is best done EOD and that might be a motive for some to take everything to EOD as mixed E3.5D and EOD will be unmanageable for most.
And ones needs/expectations do change over time and some will change what they do for no particular reason. And don’t forget “needle fatigue” after a few years.[/quote]
Appreciate the input. Do you inject EOD? Have you tried the other options?
Since starting TRT, I actually struggle with low estrogen. I haven’t had a lab come back yet with a sensitive E (Labcorp) of over 20. Easy answer is higher T but… oddly enough, when T starts to cross the 900 mark, my nips get uncomfortably sensitive. Just had gyno removal surgery on left but the right, despite no gyno, does get irritated when my T gets to high. All the while, estrogen is tested and continuously low. Anyway - to keep my own thread on track…
Part of the reason I moved from EOD to E3.5D was thinking the larger pulses would raise estrogen a bit. Didn’t really happen. Going to try and re-add HCG in the near future but who knows how long I stay on it. As I have posted in here before, I get bad sides from it at any dose.