E2 Crash with TT/FT Up. Why?

I cannot make any sense of your protocol. Please do not report volumes, report in mg’s and iu’s. You take AI once a week? If so, lab timing would determine E2 lab results. If protocol not consistent leading up to labs, results will be reduced usefulness. Fix your post of protocols above using the edit function.

AI’s do not cause bone loss in a proper TRT context. Females with cancer with E2–>zero have bone loss from low E2. With TRT we modulate E2 to a level that is optimal for energy, mood, libido and sexual function. I have been E2=~22 for 12 years and my bone scans do not show any problems. If I was not on TRT, I would be at risk of weaker bones. I can understand why this issue is here creating confusion and distraction.

Most on TRT have E2 get to where is going to be in a few weeks and intervention provided better levels that then can be stable for years. Again, such info is really derailing the learning curve.

Thyroid is a mess because you have not been using iodized salt and/or vitamins that list 150mcg iodine and 150-200mcg selenium? The normal state of most populations on the planet had been thyroid disease from iodine deficiency until iodized salt was introduced in 1922.

To eval your overall thyroid function see reference to ‘oral body temperature’ below.


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.