Question: Is it normal for E1 to remain above normal ranges while E2 reacts as anticipated on TRT while using Amridex?
Background: 53 year old male, heavy lifter 30+ years. I’ve been on TRT for approximately 6 years with declining efficacy until did my own research and discovered I had moderately high SHBG @ 50.2 nmol/L, low free T, and was converting at a high rate driving my E1 out of normal range to 111pg/ml with E2 @ 39 pg/ml. Changed my T injection schedule to 25mg x weekly (Sunday and Wednesday), started taking Boron 6mg daily, and Amridex @ 1 mg twice between injections.This protocol worked fantastic, energy and libido through the roof but resulted in a high total T of 1,221 ng/dl, E1 @ 94 pg/ml, E2 @ 10.9 pg/ml. Insurance wouldn’t cover the TRT with the total T above 900 ng/dl so put 2 or 3 more days between injections to get a lower total T and changed the Amridex to 0.5 mg x 3 between injections starting the day after I inject - this predictably dropped total and free T but also crashed E2 @ >5 pg/ml with E1 remaining high @ 86 pg/ml.
I’m a bit surprised my E2 crashed so hard but my question is why would my E1 remain high regardless of the Armidex and lower total T? Is there a way to lower E1 without affecting E2? I’ve had the assumption that E1 and E2 would rise and fall together, is this incorrect? E1 is reacting but remains above normal levels.
I’ve already reverted to my previous protocol but haven’t restarted the Amridex, rather I’m going to allow my high conversion rate to restore my E2 level then ease back into Amridex if needed but I’m concerned about my E1 also rising to such a high level.
Thank you in advance for any constructive responses and suggestions.