I am on TRT, and I am contemplating donating plasma as it pays a lot where I am (buddy just made $550 CASH in a month for a little over 2 hours a week), and a donation place is literally a block off of my route back from work.
But I am not interested in it if my testosterone is going to drop from it. Does anyone know if this will happen?
Right, and platelets are gold. Chemotherapy patients need them as chemo wipes out their platelets. Ever heard of a chemo patient that had could not have treatment because blood counts were too low? It’s the platelets, transfusion or wait a week or so for them to build back up. They’ll bleed out if platelets are low.
So, the Testosterone is in the plasma. During plasma donation, they put saline into the blood. So you removed Testosterone and put back something else. So in the short term, yes it does lower it. By how much, I don’t really know how to quantify it. If I knew how much plasma there was total, I could have a guess.
I would guess the effect is rather small, and for a short duration. A day or two later, and I would think you would be back to baseline.
So they are taking out roughly a third of your plasma. I would then think that a guy would see a short term drop in Test, by about 1/3. Perhaps right after donating, one would have about 2/3 of their previous testosterone level.
Outside of the temporary reduction in TT as it is bound to plasma (correct me if I’m wrong), is there anything to indicate this could induce a long-term effect on TT? I don’t think there is, but you are clearly more educated on this than I am
Just another outlet for your endogenous T that you produce. So in terms of your HPTGA and feedback loop, this drop in free T & free E2 would signal back to your H and P to make more T so overall positive feedback on your H and P.
Did you ever measure LH and FSH prior to plasma donations and then again after you’d been doing it awhile? I’d guess your LH and FSH would be higher after regular plasma donation; sort of the effect of a SERM but that’s just conjecture. My guess is a minor effect overall.