Does TRT Lose Effectiveness Over Time?

After 11 years of TRT, 68YO soon, it is impossible to separate things from the effects of aging. Do not expect things to be always steady. I have needed to increase T amounts to compensate, but that can only go so far. As you get older, the effects of non-optimal cortisol, thyroid and other things have a greater effect. A younger body can absorb non-optimal issues easier than an older one. All hormone systems need to be working well.

T and E2
GH/IGF-1
thyroid - iodine - body temperatures
cortisol
Vit-D3 and Vit-D25 labs. Vit_D25 is a critical hormone

Those are the big five. Keep those in good shape, and assuming one does not get other diseases of aging you will do well. Don’t abuse your body.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.