Does Injection Frequency Affect Hematocrit?

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What Benefits with Different Injection Frequencies?

I’ll posit this has to do with both dose and frequency. If I remember correctly trying to trace back the kinetics of testosterone on hepcidin suppression and to EPO, it’s first order. Once you reach saturation, you can’t make more RBCs. If your dosages are too high then daily frequency ain’t going to help if you are sensitive. Here’s an example (me at 140 mg/week of TC - 98 mg/week of testosterone): [image] Doing once weekly brings me back into physiologic range a good portion of the PK pr…

What Benefits with Different Injection Frequencies?

See the dose response of testosterone effect on hepcidin followed by saturation after going past roughly 125 mg/week. Older guys more pronounced effect. So once you elevate past the upper limit on testosterone physiologic range, no additional penalty on Hepcidin suppression (i.e. saturation) https://academic.oup.com/jcem/article/95/10/4743/2835251#supplementary-data [image] [image]