I have been on trt cream (I tried to get injectable but doctor says I will have to visit his office for that weekly since he can’t prescribe it for self use). We started on 5mg daily almost 4 months ago.
At first felt slightly better but then began to feel dizzy, burned out in afternoons, weak, etc…bloodwork showed my TT had dropped to below the range, but saliva showed an increase in FT coupled with an increase in E2…doctor increased my dose to 15mg ED with Chrysin compounded in to fight the E2 (again he feels it is effective and no need for arimidex). And he also told me to supplement with dhea and pregnolenone daily 25mg each.
Felt much better for about 2 weeks and now I am battling nightsweats, waking up nightly, dizziness during the day, increased anxiety, poor exercise tolerance, no libido etc. Can E2 be a culprit? Can the dhea and pregnolenone be? Other ideas or specifics needed?
Also, assuming only 10 to 15% absorption from creams would a dose of 15 mg daily provide any benefits or could it be causing harm by shutting down my own production and not giving anything to replace?
As a side note, my cortisol levels were previously messed up but with some supplements recent salivary testing shows I am in the normal range throughout the day. My thyroid panels have also been good.
Updates with info and lab results
Answers to KSMans basics
Can grow a full beard quickly. Not to heavy on the chest hair, sparse back hair.
-mainly carry my fat on the love handles and back
-high lipids, past thyroid nodule but no current issues
-xanax 0.25 to 0.5mg daily for anxiety
-lab results with ranges (see below)
-tend to try and eat plenty of healthy fats and protein and stay away from refined carbs since they seem to make my triglycerides and cholesterol skyrocket
-I don’t overtrain. One good day in the gym seems to knock me on my ass for a week
-have maybe 2 episodes a year where testes hurt like hell
-haven’t had morning or nocturnal erections as long as I can remember unless I have some cialis in my system.
January 30, 2012 (serum)
TSH 1.50 (0.4 to 4.5)
Free T4 1.2 (.8 to 1.8)
FSH 2.1 (1.6 to 8)
LH 1.1 (1.5 to 9.3) low
E2 16 (<39 pg/ml)
TT 419 (250 to 1100 ng/ml)
FT 69.6 (35 to 155)
February 22, 2012 (salivary results in pg/ml)
Cortisol (summary it showed afternoon tanked and then shot way up before bed)
E2 0.6 (1.0 to 3.0 males)
Progesterone 2357 (5 to 100 males) (was applying my girlfriends cream and didn’t realize the effect it would have!!!)
Melatonin 12.4 (12 to 23)
Bio Testosterone 81.3 (40 to 130 in morning)
At this point Doctor started me on 5mg/ml daily compounded testosterone cream, plus l-arginine to try and get me some energy, libido, erections, mood, etc. Also some adrenal supplements to try and correct cortisol.
June 29, 2012 (salivary)
Cortisol - levels corrected to normal
Cortisol/Dhea-S Ratio 6.4 (5.0 to 6.0 normal) High -
E2 2.2 (1.0 to 3.0) (increased since last visit)
Melatonin 8 (12 to 23) LOW - decreased since last visit
Bio Testosterone 98.7 (40 to 130) showed increase
July 7, 2012 (Serum Results) (went to Patient First because I felt like my body was going to shut down)
CBC - all good except my MCH is always slightly high
TT - 303 (348 to 1197)
TSH - 1.94 (0.450 to 4.5)
Vitamin D - 40.6 (30 to 100) seems low considering getting summer sun and supplementing 5,000 IU daily
After this visit and showing my TRT doc the Patient First Results coupled with the misery I was in, he upped my T dose to 15 mg/day with the Chrysin compounded in. He also started me on pregnolenone and DHEA oral tablets to see if they helped. They worked for about a week and now I feel like hell as stated above.
Please let me know if there is anything else I can provide and Thanks.