Distance Running and Weightlifting

I have been running more the last 7 weeks.

I have always been a lifter, my lifting has always been focused around the big 3 low reps, lower volume. On average two days a week I worked on legs, one day focused on deads and one day on squats. Well now I am starting to run I am trying to get up to 3-5 miles at a rapid pace.
Any suggestions how to break up my training now?
High reps low reps?
Any secrets that runners have?