Morepain posted this study in InTheZone's thread on Letrozole.
I had read the abstract some time ago, but failed to look any further until he posted it.
Does anyone who looked at this study have a hypothesis on why Total Estradiol increased 33% and Free Estradiol increased 39% from the six week to the six month mark?
Could the body be increasing production of the aromatase enzyme? Why?
Could the drug become less competitive with the aromatase enzyme over time?
I'm far too tired to attempt to come up with any other possible reasons. I'm curious about this because I use Letrozole for extended periods of time. I imagine those who use it or Arimidex for TRT purposes would also be interested to know. I don't currently have much knowledge of human physiology, so I'm SWAGing it at best. What do you guys think?