T Nation

Desensitized Inhibitory Neurotransmitter Receptors

Dear @Christian_Thibaudeau,

Hope you are doing well after your Australia trip. Recently through your articles, videos and podcasts that you’ve been on you talked alot about the desensitized excitatory neurotransmitter receptors (dopamine and noradrenaline). I have found those pearls of wisdom very helpful in understanding what most people would call “CNS fatique” or “adrenal fatique”. Thank you so much for that!!!

In relation to that topic I was wondering if this can happen to the inhibatory neurotransmitters as well? Are serotonin and GABA receptors likely to be desensitized one way or another? And is this something we can tackle through nutrition, training or lifestyle changes?