Epinephrines activity on beta 2 adrenergic receptors results in vasodilation, not constriction. Vasoconstriction induced by epinephrine is via alpha receptors.
That being said nandrolone does appear to delay post exercise induced PSN recovery, probably due to upregulation of said beta adrenergic receptors. Extreme stress response + drug use (stimulants typically) high dose AAS could potentially cause an adrenergic storm. But SCD induced by AAS can happen though a variety of avenues
- One could have a stroke/phat blood clot
- Myocardial infarction from atherosclerotic plaque buildup
- structural heart damage predisposing one to lethal arrythmias
- drug toxicity (catecholamine release + reccy drug use), this doesn’t apply solely to stimulants though
Seriously if you ever drink to the point of intoxication at a dance or something. Check you’re heart rate (even if not at a special event) you’ll notice (depending on how much you drink) a profound increase in RHR, sometimes even to the point of resting tachycardia if you’re active during the night (ones HR can easily hit 200 vigorously dancing while very drunk). This is due to vasodilation and the body trying desperately to metabolise and excrete ethanols (or ethanol + methanol if drinking darker spirits) extremely toxic metabolite acetomaaldehyde and alcohol induced endotheial dysfunction. Then the next day you’ll also notice increased cardiac output, potentially heart palpitations and PVC’s. I don’t ever drink anymore, however the deleterious adverse cardiovascular effects of acute alcohol intake are well documented (both acute and long term)… Interestingly even marijuana has been potentially linked (reports are very flawed, but interesting nonetheless) to acute myocardial infarction and coronary vasospasm, it appears EEEXXXTTRRREEEMEMMEEELY rare, however it does go against the argument “pots never killed anyone” that advocates for legalisation (such as myself) spew out.
Beta adrenergic receptor upregulation isn’t unique to ND, all AAS do it to some degree.
I don’t understand the allure of cocaine, from what I’ve observed (from viewing people take it numerous times), it’s a quick, stimulating rush that aids in productivity and gives the user confidence/mania initially for like 45 mins. However it blocks cardiac sodium channels and depletes the FUUUUCCCKKKK out of you’re amt of dopamine afterwards, therefore what’s the point?
- extensively cardiotoxic
- short duration
- very expensive
- crash after going off
I’ve never used cocaine and never will because I just don’t see the point, risk/reward ratio is all risk, no reward to me. I’ve just always wondered why people use cocaine as it has (typically) such a short duration of action and the immense level of risk involved makes me think there’s no point. For increased productivity… For 45 minutes… Not gonna get much done in that period of time