T Nation

D-glucurate

D-glucurate functions by inhibiting the dangerous beta-glucuronidase enzyme, thus protecting the critical “glucuronidation” detoxification mechanism. One example of the importance of glucuronidation can be seen in the risk factors for breast cancer. Excess levels of free estrogens and the beta-glucuronidase enzyme are associated with increased incidence of breast cancer.(4,5) The beta-glucuronidase enzyme is associated with an increase in the number of estrogen receptors. D-glucarate has been shown to lower estrogen receptors while reducing tumor growth.(6) When breast cells hyper-proliferate in response to excess estrogen stimulation, the risk of breast cancer increases. In men, excess estrogen stimulation in the prostate gland can result in benign enlargement. D-glucurate suppresses the “bad” enzyme beta-glucuronidase, thus helping to protect against the carcinogenic effects of estrogen. This discovery helps explain why those who eat certain types of vegetables and fruits have relatively low rates of cancer.

I posted something to the T-forum about
the aromatase inhibiting properties of
D-glucurate a couple weeks ago after reading
about it (you get LEF mag too, eh :-). Bill
Roberts response was that D-glucurate would
not be a good aromatase enzyme inhibitor
because it exerts significant amount of
activity at the estrogen receptor in dosages
strong enough to inhibit the aromatase enzyme.
BTW, did you check out the new extrodot site
yet? Pretty nice. Now if we could just get
more people to use it…