T Nation

Cutting Gel Cap Dose

Is there a way to cut the dose of a gel cap?

[quote]xXSeraphimXx wrote:
Is there a way to cut the dose of a gel cap? [/quote]

I don’t think so. I can’t remember why, but it’s a no-no.

If you break the gel cap in half, all of the liquid will spill out. So, I can’t imagine there being a way to measure a half dose.

Yes.

What are you looking to divide?

Empty it with a syringe, divide by 2.

Clearly, cutting a gel cap is a mans job!

[quote]anonym wrote:
Yes.

What are you looking to divide?[/quote]

My father will be using dutasteride but, would prefer to take smaller doses than the 0.5mg gel caps they come in.

I remember TC saying he would add a shot of vodka to a bottle add the gel cap than add 4 more shots of crystal light giving him essentially five .1mg doses. I do not know if this is ideal or even works but, my father does not drink so… Than again if it does work it is only 1/5 of a shot with each dose so maybe.

So is this a question of solubility?

Like, “is the alcohol necessary to the dilution, or will it work with water?”.

if the medicine can be frozen freeze it and use kitchen shears or a sharp knife and place the remaining half in saran wrap(so the moisture won’t be sucked out) and re freeze.

[quote]SkyzykS wrote:
So is this a question of solubility?

Like, “is the alcohol necessary to the dilution, or will it work with water?”.
[/quote]

Is the alcohol necessary or did TC want a little kick in the morning?

[quote]xXSeraphimXx wrote:

[quote]SkyzykS wrote:
So is this a question of solubility?

Like, “is the alcohol necessary to the dilution, or will it work with water?”.
[/quote]

Is the alcohol necessary or did TC want a little kick in the morning?[/quote]

Ask him yourself. He has an active livespill right?

Dutasteride is said to have a degree of water solubility of < 0.38 ng/mL (i.e., below the assay detection limit); in contrast, its solubility in ethanol is 44 mg/mL.

So, an alcohol-based medium appears to be the preferable vehicle for delivery.

While your father not being a drinker makes this somewhat problematic, consider that one ounce of liquid has a metric system equivalent of ~29.5 mL and that, say, 190-proof Everclear is 95% ABV (about as good as you’re gonna find unless you wanna swipe some anhydrous alcohol from a lab somewhere).

This gives us ~28 mL of ethanol (from an ounce) which, combined with the observed solubility and comparatively lower dose your father requires, makes it a fairly reasonable compromise for consumption (he can easily use a syringe to measure his daily dose rather than a shot glass).

[quote]silverblood wrote:
if the medicine can be frozen freeze it and use kitchen shears or a sharp knife and place the remaining half in saran wrap(so the moisture won’t be sucked out) and re freeze. [/quote]

25C (77F with “excursions” permitted to 15-30C (59-86F) per the Avodaret package insert.

[quote]on edge wrote:
Clearly, cutting a gel cap is a mans job![/quote]

lol

So, your father has not yet taken the drug and already wants to take less of it?

Was he prescribed this, if you don’t mind my asking?

[quote]xXSeraphimXx wrote:

[quote]SkyzykS wrote:
So is this a question of solubility?

Like, “is the alcohol necessary to the dilution, or will it work with water?”.
[/quote]

Is the alcohol necessary or did TC want a little kick in the morning?[/quote]

Yes, what anonym said above. You need a solute. I poke the capsule several times with a needle and place it in a shot of alcohol.

After a few hours, I add four shots of water. Each dose is then .01 mg.