T Nation

Cursed with HBP


ive been off everything for nearly 2 years and have recently been looking at running S4. Needless to say im not going to do anything that could exasperate my condition but ive been reading that S4 should be fine. Any thoughts or suggestions ?


Are you on the right BB? S4?


S4 is a SARM


this section of the forum is dedicated to those with low testosterone who need HRT to get back to normal levels.

do you have low testosterone and need help?


Found this:
Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,[1] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[2] Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs.

In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.[4] Clinical development of Andarine has been abandoned, given in humans it results in a series specific toxic metabolite [5].

here's a link to the site if you want to check it out yourselves.


HBP is High Blood Pressure or did you mean BPH? Nice having to second guess what the post is about.

Gyno and "In addition, bicalutamide accelerates the degradation of the androgen receptor."