Definitely worth a try. I trained in higher rep ranges (8-15) for the first few years, and grew like a weed after switching to a couple days of heavier lifting per week. 5x5, 4x6, 8x3, etc.
Try doing a horizontal press/pull superset (like bench variations and row variations) followed by a vertical push/pull superset (overhead press variations and pullup/lat pulldown variations).
If you still feel like you got some juice, you can do some higher rep direct arm work, although I liked to do this on a third day of training later in the week. Good luck, and be careful with that ankle so you can start squatting and deadlifting heavy and safely!