[quote]Old Dax wrote:
Found a very recent one:
Creatine supplementation improves glucose tolerance in healthy subjects.
Purpose: The aim was to investigate whether creatine supplementation has a beneficial effect on glycemic control of type 2 diabetic patients undergoing exercise training.
Methods: A 12-week randomized, double-blind, placebo-controlled trial was performed. The patients were allocated to receive either creatine (CR) (5g/d) or placebo (PL) and were enrolled in an exercise training program. The primary outcome was glycosylated hemoglobin (HbA1c). Secondary outcomes included the area under the curve of glucose, insulin and C-peptide, and insulin sensitivity indexes. Physical capacity, lipid profile, and GLUT-4 protein expression and translocation were also assessed.
Results: Twenty-five subjects were analyzed (CR: n=13; PL: n=12). HBA1c was significantly reduced in the creatine group when compared to the placebo group (CR PRE: 7.4+/-0.7, POST: 6.4+/-0.4; PL PRE: 7.5+/-0.6, POST: 7.6+/-0.7; p=0.004; difference: -1.1%, 95% confidence interval: -1.9 to -0.4). The delta area under the curve of glucose concentration was significantly lower in the CR group than in the PL group (CR: -7790+/-4600; PL: 2008+/-7614; p=0.05). The CR group also presented decreased glycemia at the time 0, 30, and 60 minutes during a meal tolerance test and increased GLUT-4 translocation. Insulin and C-peptide concentrations, surrogates of insulin sensitivity, physical capacity, lipid profile, and side effects were comparable between the groups.
Conclusions: creatine supplementation combined with an exercise program improves glycemic control in type 2 diabetic patients. The underlying mechanism seems to be related to an increase in GLUT-4 recruitment to the sarcolemma. ClinicalTrials.gov registration number: NCT00992043
©2010The American College of Sports Medicine
Hey that’s the one I was talking about!