Well, as you might guess, I'm kind of pulling for Margarito. Due to stupid mistakes I've made in life I've been the pariah a couple times, the guy nobody wants to talk to or deal with, and I always identify more the underdog lowlife sort. Watching a guy redeem himself is important to me.
And then, of course, besides that, there's the fact that Cotto is not going to win. Styles make fights, and Cotto's style is all wrong. He doesn't have the power to keep Margo at bay, and he doesn't have the boxing skills and movement to be able to stay away from him all night.
Plus, with the way he holds his hands and leans forward, he makes himself the perfect target for the uppercut, which Margarito, with those long as arms, is very adept at.
Had Cotto trained with Manny Steward and kept doing so, I would say that maybe he accumulated enough boxing skills to be able to stay away. Having no idea who the dude that he's training with now is, my guess is he will revert to the same old Cotto - slow, methodical, and ultimately doomed against Margarito. I really like Cotto, but unless he comes out with a drastically different style or increased punching power, I see this fight going much the same as the first.
Look for the rican to win rounds in the first half before folding up and eventually getting KO'd.