I have read that cortisol is better to down regulate T then E2, either way T is going to be down regulated. So the theory is guys with adrenal fatigue who have low cortisol are going to find E2 rising to control T, and then all the symptoms of E2 appear. When cortisol is normal, this helps regulate T without increasing E2. Does all this sound right so far.
Now has anyone had good success with pregnenolone raising their cortisol levels and lowering E2. I have been on arimidex 1/2mg twice a week for around 6 weeks for naturally high E2/39 and this came down to 32 and feel alittle better but further testing showed my dhea levels to be below range 2.1(2.2-15.5) and my doc wants to get dhea higher and i told him it just increases E2 which last time (oral/50mg)put it upto 54, i also ask to add pregnenolone to the mix and have a transdermal dhea50mg/preg50mg cream and doc said to increase arimidex to 1/2mg three times a week. My total T was good but freeT was low and doc said he would treat me with T after testing and see how this next protocol go's. Been on dhea and preg cream now only 4 days and feeling alittle better but to hard to judge, i take it will be weeks before feeling alot better. Before starting the creams i did have a morning cortisol and progesterone test done to help measure effects of this treatment, no results yet.
I would appreciate anyones input. Sorry if i have hijacked threads, its one of those things hwee something pops into your head and away u go, so yes sorry guys, this is a good forum where i wouldnt want to be isolated from.