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Converting Creatine Non-Responders

I read somewhere that there was some supplement or drug that may be able to convert creatine non-responders into responders, but now I can’t remember for the life of me what it was, where I read it or who wrote it.

Anyone know what I’m talking about?

I’d like to see that. I’m a nonresponder!

[quote]Nate Dogg wrote:
I’d like to see that. I’m a nonresponder![/quote]

Ditto. I can snort the stuff like coke and nothing happens.

ALA supposedly enhances the effects of creatine, so does waxy maize

Now that I think of it… it might have been ALA. Just fyi, make sure to get R-ALA.

ALA-meaning Alpha lipoic acid?

To my understanding, this is described as an “insulin mimicker” If this is the case then taking it or waxy maize will have the same effect and help with absorption in the muscles.

I do not think this will help a non-responder tho. I am not a non-responder and know very little except that creatine does not work for them. I don’t think non-responders have a problem of getting creatine ingested into the muscle. So ALA or waxy maize, etc most likely will not fix a non-responder. Correct me if I’m wrong.

Gerdy

[quote]Dirty Gerdy wrote:
ALA-meaning Alpha lipoic acid?

To my understanding, this is described as an “insulin mimicker” If this is the case then taking it or waxy maize will have the same effect and help with absorption in the muscles.

I do not think this will help a non-responder tho. I am not a non-responder and know very little except that creatine does not work for them. I don’t think non-responders have a problem of getting creatine ingested into the muscle. So ALA or waxy maize, etc most likely will not fix a non-responder. Correct me if I’m wrong.

Gerdy[/quote]

creatine doesnt work for some for a couple of reasons and one of them is insulin insensitivity. i remember reading an article and i dont remember how but ALA does help increase the effevtiveness of creatine because the science made sense, if i can find it ill post it.

[quote]diamonddelts59 wrote:
Dirty Gerdy wrote:
ALA-meaning Alpha lipoic acid?

To my understanding, this is described as an “insulin mimicker” If this is the case then taking it or waxy maize will have the same effect and help with absorption in the muscles.

I do not think this will help a non-responder tho. I am not a non-responder and know very little except that creatine does not work for them. I don’t think non-responders have a problem of getting creatine ingested into the muscle. So ALA or waxy maize, etc most likely will not fix a non-responder. Correct me if I’m wrong.

Gerdy

creatine doesnt work for some for a couple of reasons and one of them is insulin insensitivity. i remember reading an article and i dont remember how but ALA does help increase the effevtiveness of creatine because the science made sense, if i can find it ill post it.[/quote]

ALA has been shown to increase insulin sensitivity when taken in the 200-500mg per day range. Thats why a lot of people with diabetes (and pre-diabetes) supplement with it. I have no idea whether increased insulin sensitivity would enhance creatine effects tho…

[quote]diamonddelts59 wrote:
Dirty Gerdy wrote:
ALA-meaning Alpha lipoic acid?

To my understanding, this is described as an “insulin mimicker” If this is the case then taking it or waxy maize will have the same effect and help with absorption in the muscles.

I do not think this will help a non-responder tho. I am not a non-responder and know very little except that creatine does not work for them. I don’t think non-responders have a problem of getting creatine ingested into the muscle. So ALA or waxy maize, etc most likely will not fix a non-responder. Correct me if I’m wrong.

Gerdy

creatine doesnt work for some for a couple of reasons and one of them is insulin insensitivity. i remember reading an article and i dont remember how but ALA does help increase the effevtiveness of creatine because the science made sense, if i can find it ill post it.[/quote]

Creatine can be absorbed on an empty stomach so I dont know what insulin sensitivity has to do with anything.

Creatine uptake is more dependant on sodium than anything else.

I “became” a non responder. I took creatine for the first time, and it was amazing. Money problems at the time meant that I couldn’t take it any more. Two years later, I bought some more and it did nothing. What had changed in the mean time? I became a coffee drinker. These days I drop the coffee and it’s all good again. Try that if you are a non responder.

Just as a matter of interest how do you know if you are a non-responder?

I mean there are so many factors influencing muscle growth, how do you know that you are not responding to creatine?

I am sorry if this seems like a dumb question, but I am geniunely curious.

[quote]shaun1rsa wrote:
Just as a matter of interest how do you know if you are a non-responder?

I mean there are so many factors influencing muscle growth, how do you know that you are not responding to creatine?

I am sorry if this seems like a dumb question, but I am geniunely curious.[/quote]

For me, it had/has no effect on my ability to add reps to my exercises - I haven’t noticed anything significant in taking it for a prolonged period of time, and then stopping it again. Maybe I am a responder, maybe not, but I do not see anything worth writing home about from it. I do occasionally throw it in my PWO shake just so it doesn’t go stale in the cupboard.

Yeah rsg. I am the same. I whack it my PWO shakes but also have no idea if it works ot not.

It’s cheap enough so I think what the hell. I take 5mg after every workout.

All it seems to do to me is give me a headache.

[quote]Woppa wrote:
I “became” a non responder. I took creatine for the first time, and it was amazing. Money problems at the time meant that I couldn’t take it any more. Two years later, I bought some more and it did nothing. What had changed in the mean time? I became a coffee drinker. These days I drop the coffee and it’s all good again. Try that if you are a non responder.[/quote]

Anybody correct me if I’m wrong but caffiene plays with insulin sensitivity.

Caffiene is in coffee.
ALA plays with insulin to help with creatine absorption.
Maybe insulin sensitivity does have something to do with a creatine non-responder?

I’d also like to know more on how sodium affects creatine absorption, if anybody would care to explain?

Thanks

Gerdy

Weren’t some of the original research studies with creatine conducted in the UK using tea? I don’t think caffeine would have a strong effect unless you’re sensitive to it. Then again, if the number of caffeine sensitives aligns with the number of creatine non-responders there may be a relationship.

I remember reading about the sodium connection. I think creatine may be antiported with sodium, but I’m not sure.

Caffeine decreases the absorption of creatine, so do not take it with creatine.

[quote]HJLau75 wrote:
Caffeine decreases the absorption of creatine, so do not take it with creatine.[/quote]

care to explain?

Gerdy

I can’t remember which study it was, but it was to see if caffeine could increase the absorption of creatine. It turned out that it actually blunted creatine uptake into muscles.

I forget how the biomechanism worked, but all I remember is that it’s doesn’t help. So thats what I took away from it.

[quote]Dirty Gerdy wrote:
Woppa wrote:
I “became” a non responder. I took creatine for the first time, and it was amazing. Money problems at the time meant that I couldn’t take it any more. Two years later, I bought some more and it did nothing. What had changed in the mean time? I became a coffee drinker. These days I drop the coffee and it’s all good again. Try that if you are a non responder.

Anybody correct me if I’m wrong but caffiene plays with insulin sensitivity.

Caffiene is in coffee.
ALA plays with insulin to help with creatine absorption.
Maybe insulin sensitivity does have something to do with a creatine non-responder?

I’d also like to know more on how sodium affects creatine absorption, if anybody would care to explain?

Thanks

Gerdy[/quote]

hes probably refferin to the sodium potassium pump in some way