Without knowing what type of equipment you have access to it is hard to say. However, when I was high school and playing football I ran 3x per week and did cardio 2-3x per week. My weight training was full-body and pretty intense, it focus on O-lifts, as well as heavy squats, dead lifts, and presses. As far as running, I would do shuttle sprints, suicides, 40 yard dashes, and lots and lots of hill sprints. I also liked to hit the heavybag whenever I could, because I found it really improved my hand speed and upper body explosiveness, which helped me as a linemen. However, I had access to a great weight room and boxing gym, others may not be so lucky.