Dopamine depletion will occur over time when nor-adrenaline becomes very low. This won’t happen solely from drinking coffee (unless it non-stop throughout the day). Now, if you have a super high stress level, adding a lot of coffee could speed-up dopamine depletion.
The main drawback of producing too much adrenaline is that you can desensitize your beta-adrenergic receptors. When that happens performance (mental and physical) goes down. You become less motivated, more lazy, muscle tone goes down, you might have concentration issues, you lose confidence and competitiveness, etc.
2As (and 1Bs) are actually those who can tolerate coffee the best because they have the fast COMT enzyme variation (1A and 3 have the slow COMT variation). Fast COMT means that they can break down adrenaline rapidly, that’s why both 1Bs and 2As are sensitive to adrenaline: since they break down adrenaline rapidly, they have less risks of desensitizing their receptors.
1Bs tend to be better with coffee than 2As because on top of having the fast COMT enzyme, they are overmethylators, which further speeds up the clearance of adrenaline. That’s why 1Bs are often athletes who are lazy in practice and in life, but are beasts in competition.
Type 3 are those who should avoid coffee the most: they have the slow COMT enzyme, have poor methylation and low levels of GABA and serotonin (the two neurotransmitters that can counterbalance adrenaline).
Type 1A are similar: they are also poor methylators with the slow COMT enzyme, meaning that when they produce adrenaline is stays there for a very long time (makes the 1A aggressive and impatient, and the type 3 overthinks and get anxious). But since 1A have high GABA, they can tolerate it a bit better than types 3.
I would say that when it comes to the potential side effects of coffee (or stimulants) here is the ranking by neurotypes:
BEST TOLERANCE FOR SIDE EFFECTS
WORST TOLERANCE FOR SIDE EFFECTS
That having been said, 2As might have good tolerance for stimulants BUT once they are desensitized to adrenaline they will be those with the biggest drop in performance and quality of behavior. For that reason, I still prefer to play it safe with stimulants for 2As.