T Nation

Clomiphene vs Tamoxifen

Hi all,

I’m new to all things Endo, please forgive me if some of questions are very naive. I’ve found some older, related threads, but wanted to understand technically the differences. Specifically:

  • Compare/contrast (e.g. both SERMs bind to estrogen receptors in the hypothalamus and alter the HPG axis).

  • Would any TRT protocol prescribe either of these long-term? See: dark side

  • Is it possible simply using one these (i.e. without testosterone) would be effective at increasing serum testosterone?

References to relevant studies would be valuable, as would descriptions of experiences using one or both.