Clomidiphene Citrate for Low Testosterone

Hi Ksman,

For the past few days I have been measuring my temperatures under the arm and throughout the day, I am ranging from 96-97.3 degrees. After not succeeding with Clomid and Anastrozole, I started this week to take levothyroxine which my friend brought me from India. My TSH was at 4.96 miu/L on the last test, and Ive had underactive thyroid symptoms most of my life.

With low testosterone and low thyroid function, do you think its possible I could have the condition as hypopituitism? What are the odds that a relatively young person (I consider myself 16 when this started) to have both low t and low thyroid at the same time? Overnight ED since 16 years old? Don’t think its vein function because when I started Clomid I was getting perfect erections for a short while, and use to use pde5 drugs with good success, but after going on Clomid they are not working.

My doctor took a t3, t4, thyroid antibody panel and I should have the results early this week.

Ksman, do you think there is any point at all taking anastrozole on Clomid? I am considering requesting for T injections and taking it with HCG and an AI, if needed, since it seems Estrogen is easier to control while on testosterone injections then with Clomid.

Hi folks,

I just got off the phone with the doctor, well in advance of my next visit.

I was calling because I was not feeling well.

He told me that my Estrogen levels have dropped to 156 pmol/L (42 pg/mL) from 256, which was off 1 mg of Arimidex for the first few days, followed by .5 for other days, then for the past couple weeks, .25 a day or every 2nd day. I

My testosterone levels are still hanging steady on 12.5 mg of Clomid at 658 ng/DL. Initially when I was taking 50 6-months ago, my testosterone levels were up to 800.

My thyroid antibodies came back undetecable, so I really don’t know. I have Thyroxine Sodium from India but I do find my heart beating too fast and causing unacceptable anxiety levels, so i will have to play the Levothyroxine for now and cut it out until ordreded by a doctor.

I am happy to know that my Estrogen levels came down, just as I was about to discontinue the use of Anastrozole. I was prepared to block it out totally for the past two days but will keep on it and see if the drop in Estrogen helps at all.

He also told me that it takes a month or two, or three, for hormonol changes to reflect. So I need to be more patient, even though i am incredibly depressed and worried over this.

Hi guys. If anyone is interested in my case and trial with Clomid, I have a little update. I dropped the dose to 25mg for this blood test- yet my FSH and LH and Estrogen (even with A-dex) was still through the roof.

FSH 22.2 IU/L (1.4-18.1)
LH: 17.8 (1.5-9.3)
Estradiol: 156 pmol/l (downf rom 266 pmol/l prior to 1 month of .5 adex each day)
Testosterone 22.1 nmol/L (range 5.8-28)
Thyroid antibodies: Undetectable
TSH: 3.58 miu/L (last test was 4.96 miu/L)
Body temperature: 35.8-36.1 degree celcius each morning!
Cholesterol: Perfect

I’m doing everything I can guys and I am more impotent then ever. Clomid worked for me when i started it but it has never worked since. I will probably be switching to test-cyp in March with HCG and a little bit of Adex. I also started .25 mcg of Levothyroxine.

For the past month since this test, I’ve been doing 12.5 mg of Clomid each day and dropped Adex all together, hoping for better results… will find out in a week, but I do not feel better, though I have less anxiety.

My life is difficult but girlfriend is bearing with me.

why did you stop the a-dex altogether, if your estradiol is still high?

well i was guessing that after one month of .5 everyday that number might have become lower, don’t know for another 10 days when i see my results from last week.

a-dex made me feel extremely lethargic and tired, so i think.

i cut the dose of clomid in half and dropped adex at the same time, so i cant be sure…

i will wait until my blood tests come back to see what dose of adex i will resume.

the hope was, cutting clomid to 12.5 would reduce LH and reduce E2.

i always suggest taking AI’s at night due to the lethargy.

your high E2 is not likely to come down very much just by decreasing your clomid dose in half, though. it may rebound because you stopped A-dex prematurely.

oh well, take a look when you get blood work again…

I will try that… only at night! How does .25 Arimidex a day sound, with 12.5 mg of Clomid and Wellbutrtin and also 25mcg of Levothyroxine? That is my regiment now.

It seems the theory that AI doesn’t work as well with Clomid is very true, I was taking between 1mg and .5 mg a day for over a month 1/2 and it only dropped my E2 100 pmol/L, keeping it bottom of high range (44 pg/ml)

i’m confused by what you’re trying to do… if your E2 is 4 times higher than what it should be, then you’re simply not gonna feel (or perform) right. IMO, the best idea is to get that down…

if .5 mg only lowered your E2 100, then i wouldn’t use a lower dose of A-dex. i think it would be a better move to stop the clomid and continue the A-dex until the E2 is in range, and then possibly add back in the clomid later, if needed.

With high LH/FSH there can be a lot of T–>E2 inside the testes and a competitive AI like anastrozole cannot compete there. Have seen cases where very large anastrozole doses were simply ineffective. And such doses raises a concern that local T–>E2 inside the brain may be greatly reduced and with suspected negative effects. Some simply need lower SERM doses.

High LH may desensitize the LH receptors, especially sustained LH levels VS pulsatile.

Hi everyone,
Hi Saskman84,

I hope you get well soon.

we’re all on the same boat here. Please keep posting your status and what you do in order to restore your sense of well being. I am getting much information form this post. I am also on clomid now for a month + and still no labs. I am also very interested to know how much improvement one can make with Clomid and if it can be a lifetime treatment.

Please keep us posted.

Thank you

Hi Activator,

Clomid on 12.5 every other day boosted my numbers to 1000 ng/dl and it also lowered the estrogen. My initial dose was 50mg everyday, worked for a week then stopped. Then I went down to 25 a day, then 25 EOD, still high E and good T numbers. Once I went down to 12.5 EOD I went way up, problem is, I still didn’t feel better.

Yesterday I switched to testosterone injections with hcg shots every 2 days. Hoping for better outcomes, getting pretty depressed and I can hardly keep my eyes open.

Also should say, I added levothyroxine to my regiment for my underactive thyroid (4 + miu/L)

Saksman84,

When you were at Clomid for 12.5 EOD, did you see any notable changes in your body composition (how was your belly fat)?
Did you notice any strength gains?

Thanks for your contributions.

I don’t think I was on 12.5 EOD long enough to be a good example, but I did start responding to only 50mg of sildenafil citrate (while on 50mg everyday and 25mg everyday i could have taken 10 100mg viagras and probably had no effect). initially i felt big pumps on clomid, but it dwindled down to the opposite… in which i had less energy then ever. anxiety also went down.

i don’t know if its testosterone related or something else. i think i have a food allergy and i am currently trying a gluten free diet to see if thats a cause.

Hi Saskman84

Thank you for your reply.

Actually, I am now on 12.5 mg Clomid EOD. I feel good, but maybe not good enough. I have been on that dose for like a month now or even more. I have also noticed some strength gains in the gym. And with daily workout, I have noticed that belly fat is retreating a bit. I have always had this belly fat problem and i had gyno since puberty that I had surgically removed like 8 years ago. it seems to me that my hormone problems go back a long way.

I don’t have labs yet to tell what my numbers are on the new dose of Clomid. I will do labs soon and tell you. On the sexual side, I have morning wood. libido is ok. not perfect but ok. erection quality is good but not perfect. I used to do 25 mg Clomid when i started and this gave me sour nibbles. but on the new dose it seems to be ok.

KSman says that if one has a thyroid problem, it affects many parts of one’s body. I think I do have a thyroid problem. Iodine supplementation did not solve it however. my body temprature in the morning is at 36.3 C average and never goes up to 37 as it should. non MP Boldness started a few years ago. it was quite noticeable. I have had a lot of relationship stress during the past few years. maybe this is the reason. I have never tested for rT3. but don’t actually know what to do if it is high. Any thoughts?

Thank you again. I will update you all and post new labs when done.

Activator,

From what I have seen, the only people who find success on Clomid are those on 12.5 EOD or 12.5 ED. For me, 12.5 shot me to over 1000 ng/dl as opposed to 25mg a day which kept me at 600 with super high estrogen. I felt gains at the gym like you for a short time on Clomid then everything stopped working and actually became worse.

I have belly fat like you, but its a symptom of low t and underactive thyroid… but I think overall, more low t, specificailly belly fat is a specific symptom. I am only fat on my belly, nowhere else and I always exercised.

Glad to hear you are doing good sexually, I wasn’t so lucky. Clomid helped at first then made it impossible to get an erection, even with 100mg of viagra.

KSMAN is right about the thyroid. Unusual TSH is a a symptom but nobody will diagnose you until you get your T3 and T4 checked as well. I never tested for T3 because the government testing body refused (even though my doctor ordered it) because my TSH was “in range” on provincial labs, even though by US standards, at 4.97 miu/L it would be considered underactive.

Stress can apparently lower t, but I doubt if you were suffering for a long period of time that your problem would be stress related. I had ample stress as a child, when my problem started at 15. Some people think that stress can destroy your adrenal glands, but it seems to just be a theory that is not proven medically.

You need to do repeat testing for your testosterone to be sure. Temperature is apparently a given for underactive thyroid, like you, I am always under 37 too.

This so interesting to me. Why is the lower dosage more effective at raising levels? Simply less T converting to E and causing a feedback loop? But isn’t the E getting blocked at the pituitary even when it is raised?

I’m on a superhigh dose - 50mg a day. Doctor said he’d back me off to 25 EOD in 4 months.

Not sure but when I reduced the dose to 12.5 Clomid EOD, my testosterone went up and my estrogen went down. Ultimately it didn’t work out for me, even though the numbers made me look good.

I am on testosterone enenthate and hcg which have already given me a boost and for the first week greatly diminished my venous leak.

Glad it’s working out for you. I’m holding out hope for Clomid success. Maybe when my doctor gives me the go-ahead to taper down.

Still, I’m interested to know the mechanisms behind better results from a smaller dosages of this stuff. Guess I’ll hunt around the internet.

How do you feel on Clomid so far?

For me I felt good at 50 for a while before becoming worse then ever.

I had an intense high for a few weeks. Now I’m feeling back to “normal” - that is, feeling bad again.

I just got my latest results back. 150 point bump over the last month. That’s not very big.