I've got a personal thread here, but I'm interested in getting everyone's thoughts on a broader topic that concerns all of us on SERMS.
Many guys report more subjective success on lower Clomid dosage regimes. I see some guys all the way down to 12.5mg E3D. The theory proposed is that the better feelings are not the result of more testosterone than they see at higher dosages, just that the T-levels are close enough AND they're avoiding the estrogenic effects of too much zuclomiphene.
There's a second theory that too much Clomid might actually be less effective at inducing testosterone production than medium or low dosages; perhaps there's a bell curve type effect, where the body scales back after a certain amount of the enclomiphene.
Despite these theories, I don't see a lot of guys showing bloodwork at various levels. Here's what I've got:
360 Total T (Reference range: 250-1100)
79 Free T (35-155)
14 E2 (>/= 29)
FSH: 1.9 (1.6-8.0)
1 Month of Clomid 50mg/day
520 Total T
170 Free T
4 months of Clomid 50mg/day
520 Total T
170 Free T (again)
1 month of Clomid 25mg/day
420 Total T
105 Free T
The important caveat about the 25mg/day is that I had been dieting at -500 kcal/day for about 4 months at that point and was down to roughly 8% bodyfat. That probably wreaked havoc on my hormone levels.
What interests me is that I had lower T and Free T levels at the lower dosage, but with a higher LH value. I wonder if that means that the lower dosage WOULD provide a larger T bump had I not been dieting.
That gets around to this question then: is the typical drop in testosterone from a caloric deficit caused more by:
1) Reduced activity at the pituitary - usually less LH being produced, as the body makes some budget cuts to compensate for the energy deficit.
2) Reduced synthesization of testosterone in the testes
My experience militates towards the latter, which would mean I should continue the lower dosage when I'm out of the caloric deficit. But one guy's results don't mean much so I'd like to know if anyone else has any theories or experience about this topic.
Subjectively, I felt the normal Clomid high two weeks after first beginning, and then settled back into a better-than-pre-Clomid groove. When I dropped the dosage, I didn't feel great, but I think that may be related to the dieting.
Perhaps the next experiment is trying an even higher dosage than 50mg/day and seeing what happens.