There are two things contributing to high E2. One is TT=1030 and the other may be high LH creating higher than normal T-->E2 in the testes. Anastrozole will reduce the T-->E2 driven by serum T levels, but will not have much effect at all on T-->E2 inside the testes. You can start of with 1.0mg/week in divided doses. I expect that you may need 1.25mg/week with that TT level.
We also see high E2 levels with high dose hCG that cannot be managed with anastrozole.
You will feel a lot better getting rid of that estrogen poisoning.
Where are you located?
You can use less clomid [or nolvadex] and add injected T and your testes will be fine, or T+hCG. This would lead to less E2 from the testes.
Some of the negative estrogen effects that you are experiencing could be from clomid, which really is an estrogen from a chemical point of view. Clomid can make some really feel messed up from an emotional point of view.
Nolvadex does not have those problems.
Clomid is prescribe very often out of habit and convention. Nolvadex can work as well and have less problems. Getting a doc to change what he does is another issue.
Noting that a SERM is meant to protect your tissues from the effects of E2, you are having a lot of negative effects. Remember that the "S" in "SERM" is Selective, not all tissues are subject to the SERM action and the tissues that are not are exposed to the higher E2 levels. Note that SERMs typically do increase E2 levels. From my point of view, all SERMs should be used with an AI.
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