T Nation

Clen, Benadryl and Post-clen


#1

I'm interested in hearing about people's experiences with clen. Particularly the concurrent use of benadryl with clen. Also, what people did on discontinuing clen? Did you guys jump to an EC stack or HOT-ROX and slowly decrease the does or just stop without using and supplements after your cycle?


#2

As you know, Benadryl, at around 50-100mgs/night before bed (every 3rd week or so, for that week) will help with keeping your beta-receptors working properly. Beta receptors are embedded in the cell's outer phospholipid membrane. The stability of the membrane has a lot to do with the proper function of the receptors.

Methylation of the phospholipids is stimulated by the binding of beta agonists to their receptors. Methylated phospholipids are foreign to the body, and when the body recognizes tham as foreign, it breaks them down with phospholipase A2. This changes the structure of the outer membrane which results in desensitizaton of the beta receptors. On the other hand, agents that inhibit phospholipase A2 slow desensitization.

Cationic ampiphylic drugs are known for their ability to inhibit phospholipase A2. Benadryl (diphenhydramine) is a cationic ampiphylic drug.

Ergo, Benadryl slows desensitization of Beta receptors (i.e. Upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly.

This will allow you to use clen for much longer and it'll still have the same effects. Also, since Benadryl is an anti-histamine, and histamines have a direct effect on beta-adrenoreceptors (not just Beta-2?s but all of them), using an anti-histamine will have a direct effect on reducing beta-receptor stimulation, and thus upregulating your beta-receptors.

In addition, many athletes have issues sleeping while on clen, and Benadryl before bed can help with that.

Finally, stimulants are well known to cause Anxiety in some, and clenbuterol is a stimulant; Benadryl is widely prescribed as an OTC anti-anxiety medication, when people go to emergency rooms with classic panic attack/anxiety symptoms.

SO using benadryl with your clen will upgrade your receptors, help you sleep, and avert stimulant based anxiety.


#3

Thanks, Anthony. Any other opinions/experiences anyone wants to share?


#4

even low dosage, it makes me feel like absolute shit. which is a shame because I have a large quantity of it. Interesting tho about the benadryl, might give it a try

Dezz


#5

Thanks for all that info. In theory, if one were cycling ephedra for neural drive or fat burning, would using benadryl help to re-upgrade your response after a few weeks?


#6

Also, it sounds like Benadryl might work for helping get through the nervousness of breaking a caffeine or nicotine addiction. What about as part of antidepressant tharapy?


#7

Yes. It can help with that also.


#8

Actually, as an aside, Benadryl helped me coming off of the anti-depressant Effexor. One of the side effects of withdrawal from an SSRI like that one are those so called "brain zaps". So, it doesnt suprise me that it affects receptors and neural function.


#9

so like this:

week 1 clen ed
week 2 clen ed
week 3 clen ed benadryl ed
week 4 clen ed
week 5 clen ed
week 6 clen ed benadryl ed

???