T Nation

CLA Side Effects?

From Wikipedia. How much of this is true and how much of it is bullshit?

Some studies of CLA in human diets show that it may reduce body fat,[25] , especially abdominal fat. A maximum reduction in body fat was achieved with a daily dose of 3.4g.[26] However,experts do not recommend taking CLA supplements. CLA supplements contain high levels of the t10,c12 CLA isomer, which has been linked to multiple side effects.[27] Supplementation with this form of CLA has been shown to increase C-reactive protein levels, possibly to induce oxidative stress,[28] to reduce insulin sensitivity, and to increase lipid peroxidation.[29]

However, the significance of these findings is unknown, and other studies suggest that CLA may protect cells from oxidative damage by increasing glutathione levels without inducing lipid peroxidation.[30] It is possible, however, that the observation of markers of increased lipid oxidation may indicate potentially desirable lipolytic effects. Further studies are necessary to establish the clinical significance of such observations.

Possible adverse effects of CLA in humans

There are concerns that the use of CLA by overweight people may tend to cause or to aggravate insulin resistance, which may increase their risk of developing diabetes.[31][32] However, the evidence is controversial, and some studies showed no changes in insulin sensitivity.[33][34]

In one study CLA produced a 32% increase in biliary cholesterol concentration which increases the chance of gallstone formation.[35]

In 2006, a study by the US Department of Agriculture suggested that CLA can induce essential fatty acid redistribution in mice. Changes in docosahexaenoic acid (DHA) and arachidonic acid (AA) levels were observed in some organs. For instance, certain CLA isomers reduced the DHA content of heart tissue by 25%, while in the spleen, DHA content rose, and AA fell.[4]

A study of CLA supplementation in hatchling chicks (2005) showed high mortality and low hatchability rates among CLA-supplemented groups, and also a decrease in brain DHA levels of CLA-treated chicks[1]. These studies raise the question of whether CLA may increase the risk of cardiovascular and inflammatory diseases, but it has yet to be established whether such changes occur in humans, and whether they are clinically relevant.

I’m just posting in here so I get notified with updates. It seems interesting.

Yeah it would be nice if one of the big wigs would chime in with their opinion.

I’m neither a hatchling chick or a mouse, so I think I’ll be okay.

[quote]esk221 wrote:
I’m neither a hatchling chick or a mouse, so I think I’ll be okay.[/quote]

It goes a lot deeper then that. Thanks though.

I’m surprised this isn’t getting more responses. It seems like one of the biggest debates going on right now in sports nutrition. Probably deserves it’s own article.

Then don’t take CLA, ya’ big pussy!

[quote]esk221 wrote:
Then don’t take CLA, ya’ big pussy![/quote]

Nothing wrong with being curious.

[quote]esk221 wrote:
Then don’t take CLA, ya’ big pussy![/quote]

Like I would take criticism from anyone dumb enough to take a picture like that and put it on the internet thinking it was somehow cool.

[quote]chimera182 wrote:
esk221 wrote:
Then don’t take CLA, ya’ big pussy!

Nothing wrong with being curious.[/quote]

Don’t ask questions, Just believe… That would be his motto and a few others judging by the way this place turns into a ghost town when a controversial issue is brought up.

[quote]fightnews10 wrote:
esk221 wrote:
Then don’t take CLA, ya’ big pussy!

Like I would take criticism from anyone dumb enough to take a picture like that and put it on the internet thinking it was somehow cool. [/quote]

Oh, I’m sorry - I thought this was a bodybuilding forum. I happen to think my legs are very cool.

But seriously, in the absence of any conclusive studies proving the “dangers” of CLA, I would just stop taking it if I were you.

[quote]esk221 wrote:
fightnews10 wrote:
esk221 wrote:
Then don’t take CLA, ya’ big pussy!

Like I would take criticism from anyone dumb enough to take a picture like that and put it on the internet thinking it was somehow cool.

Oh, I’m sorry - I thought this was a bodybuilding forum. I happen to think my legs are very cool.

But seriously, in the absence of any conclusive studies proving the “dangers” of CLA, I would just stop taking it if I were you. [/quote]

Why do you say the studies are inconclusive? There was a study done in 2005 of all the studies to that date that was pretty interesting if you want to look it up. Some people seem adamant that it does the opposite of what it claims. Their is credible research supporting both opinions. I sent an email to the man that discovered CLA and I’m hoping I get a response with his opinion.

I’ve never seen one, but I’d be interested in reading about said findings. I read the same info about CLA causing increases in LDL awhile back and since I never noticed any real effect while taking it, it was pretty easy to drop out of my supplement regiment.

I have a bottle of it, it doesnt seem to have made that much difference. I was only take 1000mg with 4000mg fish oil to make my own Flameout when I couldnt get any. If I forget to take it, I dont worry.

Maybe there’s mis information about CLA put out by companies that make advil or aleve seeing as it seems to work a lot better with no side effects. What do you think,

i noticed i lost some stomache weight with CLA

Just got my email back from DR Michael W. Pariza He didn’t say much but here it is.

Tonalin and Clarinol CLA (produced by different companies under license from the Wisconsin Alumni Research Foundation, the IP are arm of the University of Wisconsin) are now both accepted by FDA as “Generally Regarded as Safe” for food use (see attached). These CLA products have been thoroughly tested for safety and efficacy.

Best wishes,
Michael W. Pariza
Professor of Food Science

He attached two documents saying how it’s just been approved to add to food like yogurt and shit like that. And that it builds muscle. Whamo!

That’s big news, I thought someone would have an opinion on it. Anybody know how to attach a file to a post? I’ll put up the stuff he sent me.