T Nation

Chronically Elevated LH Long Term Damage


#1

I've had elevated LH for at least a decade (LH always above top of normal range). I asked my urologist what the long term health impact would be if I continued to have high LH. He said "nothing". Wow.

I'm making a list of potential negative health effects due to chronically elevated LH. Please post if you know of any that I miss, or if you have references in addition to the ones I list below.

  1. Leydig cell desensitization

"Hormones and their actions", Volume 18, Part 2 By Brian A. Cooke, Roger John Benjamin King, H. J. van der Molen
http://books.google.ca/books?id=KQstnA8Bb58C&lpg=PA172&ots=QmVWOrf71s&dq=elevated%20LH%20leydig%20cell%20desensitization&pg=PA172#v=onepage&q=elevated%20LH%20leydig%20cell%20desensitization&f=false

  1. Early onset Alzheimer disease

"Dysregulation of the Hypothalamic-Pituitary-Gonadal Axis with Menopause and Andropause Promotes Neurodegenerative Senescence", Atwood et al., J Neuropathol Exp Neurol, 2005 (http://p973.ccmu.edu.cn/4-zuixinjinzhan/1/7.pdf)

Of interest: "Can regulating LH halt Alzheimers?" http://alzheimersweekly.com/content/can-regulating-lh-halt-alzheimers

Also: http://www.curaxispharma.com/index.php?option=com_content&view=article&id=22&Itemid=29

  1. Testicular and Adrenal cancer

"High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene", Mikola et al., Oncogene (2003) 22, 3269â??3278. http://www.nature.com/onc/journal/v22/n21/full/1206518a.html

  1. Elevated estradiol (and follow-on health effects of elevated estradiol)

"Acute stimulation of aromatization in Leydig cells by human chorionic gonadotropin in vitro", Valladares and Payne, Proc. Nat. Acad. Sci., 1979. http://www.pnas.org/content/76/9/4460.full.pdf

--
EDITED December 11. Additional web link added under Alzheimer section.


#2

This is a good idea for a thread. I think if we have knowledgeable people help build it, we can get it stickeyed eventually.

I would like to eventually add a discussion on WHY your LH can be chronically elevated, and things to do to both diagnose and correct that issue.

Work in progress.