I posted this earlier in a different thread:
I disagree with the suggestion that cholesterol lowering drugs would be of unqualified benefit, as statin drugs can easily reduce CoQ10 levels, lowering mitochondrial activity which can simply replace heart attack events with death by congestive heart failure. CoQ10 supplements are needed with statin drugs. I need to tell a story: An older friend had a ongoing nagging cough. I asked if he was taking Lipitor. He responded, surprised that I asked, that he was on 40mg, [a large dose]. I gave him a bottle of 100mg ubiquinol CoQ10. His cough is gone and he has lost 17 pounds, a long term sore elbow is also “healed” [cannot explain that]. As he burns off his own fat, he eats less. 17 pound of fat is a lot of calories. He continues to loose fat. I notice that his blue jeans all look new too. [Constant coughing is a major symptom of congestive heart failure. A weakness in the heart causes back pressure in the lungs forcing fluids to accumulate in the lungs.]
How can you say that “There is some legitimate concern that statins may worsen heart failure, but that’s an entirely separate issue.”
Hey doc I have congestive heart failure. [Doc replies] “but that’s an entirely separate issue.”
These things are not rare for those affected. Why do you even want to start playing down the fact that statin drugs lower CoQ10? I know why drug reps would want to do that. What is wrong with advising people to take some CoQ10 to avoid a therapy induced CoQ10 deficiency? If you have to sell a negative aspect of statin drugs, then that is the way that it should be.
Why do you people send the OP to quack pseudoscience? He’s a very high risk patient. Do you want him to die from a heart attack at 45? His LDL is literally in the very highest category and the very highest risk. High cholesterol is an exceptionally well established cause of atherosclerosis and risk factor for stroke and heart attack. There’s literally more than 40 years of evidence on this point. (Look up the Framingham heart study). There’s almost as much evidence that lowering LDL lowers risk for heart attack and stroke, and, if you lower LDL enough, you can get regression of atherosclerosis. The good news is that he doesn’t have any other risk factors – yet. (Unless he had near relatives die from a heart attack or stroke at a young age).
Heart failure and coronary artery disease different diseases. Statins are NOT INDICATED for patients with heart failure. CHF patients were excluded from most statin studies. So no one actually knows what the effect of statins are in that patient population. That’s why we do research. As of a few years ago there were a couple of large studies pending.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1551909/ I’m not sure of the results of that research. Now, if a doctor has a patient with elevated cholesterol and heart failure, he has some choices to make based on the limited data available and the drug options.
Statins almost certainly don’t cause heart failure, but they may worsen it in people who already have it. Or not. The evidence is up in the air.
You don’t get how drugs are regulated. Unless it’s on the label approved by the FDA, the drug reps basically can’t talk about it. It’s more complicated than that, but that’s the gist. The FDA fines the crap out of companies for off label claims. And, as I showed you, there’s no conclusive evidence CoQ10 supplementation is necessary or even helpful. There are two studies and they have inconclusive results. The drug reps (or even the drug companies) can’t say oh, by the way, you should take CoQ10 with this. Not without facing penalties. That’s up to the FDA and what’s in the FDA approved label.
And don’t give me one-off anecdotal evidence. That means jack shit. Show me a clinical trial.