Serum E2 is a balance of E2 production and E2 clearance in the liver.
Need liver lab data: AST, ALT, CK
E2 is from FT–>E2 and the more FT, the more E2
More T means more E2
Anastrozole needs to match serum T levels, more T needs more anastrozole.
Liver clearance can have interference from some drugs. List all meds, Rx and OTC. Read the things that damage your hormones sticky.
Are you testing progesterone levels!?
We have never seen SHBG as a therapeutic target like this before.
Need labs in list format with lab ranges.
Do you have pre-TRT LH/FSH?
Inject T twice a week, subq better than IM
Take anastrozole at time of injections, 1mg anastrozole per 100mg T
250iu hCG subq EOD to prevent loss of fertility
Are you taking a SERM [clomid or nolvadex]?
Please read the stickies found here: About the T Replacement Category - #2 by KSman
- advice for new guys - need more info about you
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.
KSman is simply a regular member on this site. Nothing more other than highly active.
I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.
The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.