Of course there is, and it’s a pretty bad idea to do this. Check this out:
Basically, megadoses of vitamins can cause vitamin toxicity and the harmful effects depend on what vitamin you had too much of. I don’t think the vitamins would necessarily inhibit the body from metabolizing creatine or food or anything else though, but I am not a doctor.
Edit: To better answer the question, I found a couple more links.
"Combining supplements will not normally interfere with the way they work and in some cases may be beneficial. However, certain supplements may interact with each other, for example, there is competition within the gut for the absorption of different minerals and a large dose of one might decrease the absorption of another or cause excessive absorption of another. Generally speaking though, this is not a problem. Take vitamin D and calcium for instance. No matter how much calcium you take, it will not be anywhere as beneficial as if you took a moderate amount of both vitamin D and calcium together. "
And then from:
“Because of the demand that large doses of creatine monohydrate powder, with its limited solubility, place on the need for hydrochloric acid in the stomach, there is a risk of producing an HCL deficiency state or the presentation of Achloryhdria. In addition to being involved in protein digestion, hydrochloric acid serves as a potent bactericidal agent and plays a key role in the absorption of vitamins and minerals, and in particular, vitamin B12 and the prevention of anemia. A deficiency of HCL resulting from excessive creatine monohydrate powder supplementation may also cause such symptoms as heartburn (burning sensation in the epigastrum), flatulence and diarrhea.”
So, yes, they could definitely interfere with each other, but we may need a biochemist to explain what exactly will happen