My wife always had muscle sores just right before her period. It stayed for whole month but just right before period it always got worse. Neck and back area, like pain you have from sitting too much on phone or laptop, except she doesn’t
Now, I started TRT 3,5 years ago and… I started to get muscle pains - my E2 is ~70 most of the times.
So that’s my detective work - what You say?