Can Anastrozole Stop Working?

I am to the point now that I have to take 1/4mg of anastrozole every day to keep the estrogen down. I used to be an over responder needing to only take 1/4mg every 4-5 days. Why the change? Does it loose it’s potency after a while? I’ve been on TRT for about 4 years. I switched to every day subq shots since that keeps my moods more stable. I’m actually in a good place, but it seems like I have to take it more frequently than I used to. Worried that it will just stop working or something.

Thanks in advance.

Have you validated this with blood work or are you basing this from how you feel?

Have you introduced hCG or a SERM [clomid, nolvadex etc]?

Your serum E2 levels are a balance of T–>E2 generation and metabolization/clearance by the liver. AST/ALT labs of interest. Some drugs, Rx or OTC, can interfere with liver E2 clearance.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.