@unreal24278 this is mainly a question for you because it seems like you get a kick out of this kind of thing but anyone else that can add any info would be much appreciated.
So I started taking Tamoxifen after reading the “ask physiolojik” thread. I was doing some random reading and noticed that bupropion supposedly has a major drug interaction with tamoxifen (as well as many SSRIs though bupropion is not an SSRI). It seems to do with bupropion reducing the activity of CYP2D6 which is responsible for breaking down the tamoxifen.
I know you are busy but when you get a chance could you take a look at this and see if you agree with the findings? I’m trying to determine if I need to try and come off bupropion. Of course the easy answer is yes but it’s going to be a major b-word that I’d rather not go through if I don’t have to.
Bupropion 300 xl - 5+ yrs
Tamoxifen 20mg - 3 weeks