T Nation

Blocking Androgen Receptors in the Hypothalamus?


I’ve been doing a little reading about the HPTA, as I’ve been considering TRT and want to understand what it really does. This led me to a (perhaps stupid) question.

It seems that standard practice is to use HCG in addition to supplemental testosterone if one wants to preserve his natural ability to produce testosterone. But HCG doesn’t really deal with the root of the problem, i.e. that when you supplement your testosterone, the hypothalamus detects excess androgens and shuts down the hormone chain that leads your testicles to produce T. It just provides a substitute for one of the products from halfway down the chain (LH). It seems the ideal would be to block the androgen receptors in the hypothalamus so that it doesn’t detect the excess T in the first place, thus preserving the normal operation of the HPTA. Is there nothing that can do this?