i setup after every rep. so a set of 5 is actually more like 5 sets of 1. i have two deadlift days now each week. one being a heavy day, moving up to multiple heavy singles and then a lighter dead day of either speed pulls or deficit pulls. these are done for sets of triples for multiple sets. i do all of these with a double over hand grip. my heavy days are done with double over hand until the weight causes my grip to slip then i switch to mixed grip.