BBQ- Phills BBQ in Hillcrest/Oldtown
Italian- Tiramisu Trattoria in La Mesa
Dine in Pizza- Fillipi's Pizza Grotto in Little Italy
Take Out Pizza- Best of Sicily in Casa De Oro
Mexican- Murrietas in La Mesa
Take out Mexican- La Posta de-Acapulco's, in Casa De Oro. It's one of those hole in the wall joints nestled next to a bar and a pawn shop that kicks down kick-ass carne asada, and their hot sauce is amazing, especially after it sits in the fridge for a couple days.
Seafood- Brigantine, it's technically a chain, but I like the Poway Location the best.
Best overall food, locations, ambiance, and huge big screens for sports... Trophy's In La Jolla, Mission Valley, and La Mesa/Grossmont