No. I don't think would. I know it. From personal experience and from training others.
If you are training in a bodybuilding sense, you do whatever it takes to get the results you're looking for. I have switched my leg routine around quite a bit trying to stimulate my lower quads, and I've found that doing squats last helps a lot. I start with isolation lifts for both quads and hams, and finish up with 3x10 squats. It makes the squats suck that much more (um, i mean... makes them that much more awesome), but my entire thigh feels much more worked the next day.