T Nation

Ask Physiolojik Thread

Ahahaha, have you watched Orphan Black and the neonutionalist. Bloody great show.

The guy in Sydney who got charged for hacking his opal card to insert a rfi chip in his hand.

It will happen

Exoskeletons are already being trialed by us military

This question wasn’t directed at me, however are you taking 4 baby aspirins/day or four regular aspirins each day, either dose wouldn’t be recccomended, however 4 regular aspirins has a higher chance of getting you into shit. A gastric ulcer is fucking painful, NSAIDS like aspirin interfere with gastric mucosa’s ability to protect itself from damaging acids, hence why many people get an upset stomach from NSAID’s. Personally in my chronic pain days there was a point where I’d take like 2000mg of naproxen/day + ibuprofen + acetomitophren (and on top of that I’d sometimes still drink beer, I wasn’t aware of the risks at 13-14 y/o… Wait… I mean I NEVER drank beer at 13), I never had any issues but I know a few people who have aquired stomach ulcers from chronic NSAID use. (NSAIDS, mostly certain NSAIDS of the COX-2 selective inhibtors class are cardiotoxic, I believe ibuprofen and naproxen are, don’t think aspirin is particularly so though). Nephrotoxicity is also a concern with chronic NSAID use. That being said a baby aspirin a day to reduce the chance of stroke with high RBC/HCT is fine, but 4 aspirins a day… come on there isn’t really any benefit after a while. It’s like if there a difference between 3 and 4 grams of test/wk other than an increase in side effects?

An option you haven’t considered is simply lowering the dose, it’s possible 500mg is too much, try 400mg/wk. It’s always best if possible to get by without resorting to additional polypharmacy. 400mg will still net great gainzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzz. For me personally, I get androgenic side effects from testosterone. I’ve always been very hairy for my age, however on the higher dose of test it’s gotten so out of control people are giving me shit for it (because it looks a bit strange, I do shave my body hair but it grows back too fast. I have copious amounts on my stomach, back, arms, legs, shoulders, face, chest, toes, ass… I’ve always had a significant amount of body hair, especially for my age #precociouspubertypriortoacquiringhypogonadism, but a young looking face… so it looks a bit off haha, I was that 12 y/o kid who was already shaving lol. Anyway, with the test I can either, lower the dose, put up with it or find a less androgenic compound my body can tolerate. Given that extensive growth of bodyhair isn’t as serious as high blood pressure, I’ve chosen to just put up with it, with HBP (a condition that can have a myriad of serious consequences such as hypertrophic cardiomyopathy (also a risk factor from AAS use and frequent heavy lifting alone, but far moreso with AAS), kidney damage to in extreme cases outright renal failure, stroke and more. I’d lower the dose, adex can do a number on the lipids, if you’re gonna take adex, then get lipid monitering, and make sure you don’t crash ur estrogen, it’s vital for so many aspects of optimum bodily functioning.

Hey @unreal24278, 2 asproclear morning and 2 at night. Not everyday, minimum 2 a day. Depends how im feeling.

I have, and i will if i cant manage effectively. Im start to shape up nicely and after last night’s anastrozole drying up a bit. Its looking good.

I have brought out my old CPAP machine to see if im having an interrupted sleep. Only 2 nights in so it wont have a drastic effect yet.

Ahh poor fella, im fair haired unlike my old man who is an ape.

Im constantly doing bloods. In 2 weeks we are doing another full blood panel. My LDL was a little high after my cut. We put that down to a bit of dehydration.

On the 15th im going to fork out for the blood donation.

Thanks for your concern dude, really appreciate it. Just want you to know im monitoring daily,/weekly.

I have too many great days in my life ahead of me to ruin.

Im loving my sex life atm, i broke my mrs last night. She took a tremadol just so i could fuck her for a 4th time yesterday.

@physioLojik I was searching this thread and I think I could not find anything.

What’s your thoughts on subq v IM?

Thank you.

I’m not physio but I will say I have done both subq as well as IM. I have bloodwork on both and my levels for TT ft and e2 were identical. I noticed no difference in anything whatsoever except the fact I got painful lumps under my skin doing subq. I really didnt like that so I’ve been doing shallow IM at the delts ever since.

@charlie12 I think sub q is super over rated. The ONLY time it makes a difference is in very overweight ppl and in that case they need to not be on TRT until they can get some of their weight off. The medicine is created for IM delivery. While it can work subq, it’s like saying you should take a medicine designed for oral use rectally. It’ll work. But not a great plan.

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There was a dude on here who made a thread asking if he could take stanozolol rectally, I told him to take it intraurethrally… Then the thread got taken down. This was in the timespace of a few hours I believe.

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As my topic gets little traction, and you are very knowledgeable on the subject, I thought I would pose my question here:

I have a question with regards to keeping fertile while blasting and cruising.
Despite the fact that I have been reading quite a lot on this subject here, I have not been able to find a definitive answer to the question of how fertility is impacted when blasting & cruising, given that one also uses HCG.
Let’s say I would do moderate blasts of 350mg Test E and 250mg Mast E, followed by a cruise of 125mg Test E. Would injecting 250mg HCG E3D be sufficient te keep my fertility?
If I would decide to start with attempting to have children (in about 3 years time), I would stick to a TRT dose + HCG. Is that protocol OK?

Thank you for help!

@bigdawg12345 hey man! I would drop the hcg until it’s a time you actually want to start trying for a baby. Your body becomes insensitive to it and there isn’t a need for it until you’re ready :wink:

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Wait a minuteledoodle is leydig cell desensitization from HCG more than just a myth? I’ve seen the rat studies but never seen any concrete evidence for humans. I’ve never used HCG (and never will, concieving a child wouldn’t be possible for me considering the fertility issues BOTH my parents had (I’m IVF Woot, born at just under seven months old), and then there’s the whole hypogonadism fiasco with LH and FSH still in range after 6 months on trt hinting at a possible issue with my testis.) @physiolojik

Wait, shit, he’s probably on a plane, watch snakes on a plane… On a plane. But on a different plane because if you ever see this it’s too late, and then you can be one of those people whoose like “I saw snakes on a plane on a plane” and people will be like “what the hell are you talking about”

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@physioLojik

Hey doc. I think I may finally have a good question for you.
Thanks for your time.

TRT 1 Year Update

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@physioLojik just a quick question about HCG: Is it sufficient to restore fertility on its own, or does it need to be used in combination with other drugs?

I started on TRT about twenty months ago, and haven’t been on HCG in that time. If I can get some function back “down there” when I need it, then that’s good to know.

That said, I had a semen analysis run a couple of weeks after starting, and the count came back around 250,000 per mL. Would I be right in thinking that testosterone wouldn’t have had that much of an impact at that time? So there might not be a lot to get back!

@unreal24278 currently at the polaris lounge in Newark. Give me some time and I’ll answer.

@physioLojik, would love to hear your opinion on some historical e2 sensitive test I have run in relation to test dosage:

8/15/18- 120mg Test Cypionate E2 sensitive 29.6 pg/mL
9/20/18- 100mg Test Cypionate E2 sensitive 26.4 pg/mL
10/25/18- 160mg Test Cypionate E2 sensitive 28.1 pg/mL
I dont really have anything to complain about just surprised at the lack of movement in regards to my E2 levels. Seems like not matter how high or low I go it stays relatively the same. I’m still running 160mg Test Cypionate at the moment. I’m tired of playing these little E2 games as I’ve been curious as to how much Test would put my E2 over range. I thought for sure 160mg would do it but nope. I just ordered a ton of nolva. I think I’m just gonna run a low dose blast of Test only for 12 to 16 weeks and continue to monitor E2 levels. Any thoughts on any of this?

Do you inject im?

@physioLojik I asked a question above and was wondering if you could give me your 0.02. My doc wants me to take saw palmetto to lower my DHT (have no idea what it is at and no symptoms of higher DHT except balding but that was before TRT). His thinking is if I lower conversion in turn would raise my total T. I personally didn’t think it would work that way, it would make sense with free T but not total to me, but I’m new at all this. Hope to get your opinion so I stop questioning my doc’s knowledge or know I need to start questioning even more. Thanks Doc.

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I do inject IM. Shallow IM Delts with easy touch 28 gauge insulin needles.

So, I saw before that @physioLojik, you’re not a fan of AI use unless absolutely necessary. I even seem to recall you suggesting 10mg/day of Tamoxifen/Nolva in “ambitious” TRT instead of any low dose AI. Having done my research, I partly seem to get where you’re coming from (no “free lunch” with these AIs), but there’s a part that I cannot seem to get my head around. It’s the conflict of two facts(?) I cannot resolve.

  • Nolva acts as an anti-estrogen in the breast tissue, but acts as an estrogen agonist in other tissues.
  • gyno is the result of a seriously neglected rise in E levels in men. At least for me, moon face, lack of energy and motivation, etc. were already significantly present when my nipples were just itching a bit, but not swollen yet at all.

So, what’s the point I’m missing when I don’t understand why we should use a specific anti-gyno medication that does not(?) treat all the other side-effects that come sooner than gyno itself. (Or maybe even adding insult to injury being an E agonist elsewhere.)

Thanks in advance for helping me see more clearly here!

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Nah man don’t worry about it, enjoy you’re holiday, I’ll annoy you about it when you get back lol.

I don’t think I’ve ever been in the Newark longue, but I have been in the quantas and Emirates longues before, I’ve gotten funny looks before though because I don’t dress sophisticated or quite look the part.

Alright I’m sorry to bother you on you’re holiday however something happened that I thought you and everyone on here should probably know about. So, I had a final exam coming up, one of the super important exams that determines what course I get into after school, goes towards a decent portion of my atar, which is the Aussie equiv to GPA/SAT scores or however they do it there. Anyway as a child I had ADHD, so I took amphetamines (prescription) to counteract the hyperactivity, I stopped taking them when I was about twelve due to certain adverse effects (extreme appetite suppression, certain ones made me borderline psychotic, however I ended up on Focalin (dexmethylphenidate), which had no side effects besides the appetite suppression, but as I got into lifting weights I decided to stop using it due to the appetite suppression so I got my doctor to wean me off. Now I still have a huge bottle of this stuff lying about, I’ll explain how this factors in soon. Now earlier you said you’d never judge me, but I’m sure you’ll judge me to the extreme with what I’m about to say.

To study more efficiently and for longer durations for the final exam, I took 5mgs of dexmethylphenidate the day before the exam. I would like to point out this is not something I do on a regular basis at all, maybe individual five times a year to help study for exams, and that’s just started this year. Due to anxiety, I couldn’t sleep that night (and I had gotten up early the morning prior), so studied through the night, but found myself getting very, VERY tired at around 4AM, considering I had to get up in two hours, I couldn’t risk going to sleep and not getting up, so I took 200mgs of caffeine (pill form), and my body HATES caffeine, I get diarrhea, tachycardia, heartburn (no point into going into mechanisms here, I’m sure you guys know why this happens with caffeine), and then three hours later before the exam I took another 5mgs of dexmethylphenidate as it helps me concentrate for hours on end (seriously when I’m not on it my attention span is so short I have to study in 15 minute increments). Anyhow, that morning due to anxiety about the exam and the stimulants in my system I had a full on panic attack, something that I’ve never had before and it SUCKED, there was pain in my chest, rapid heartbeat, I was nauseous (HR was already rapid due to the stimulants), I knew it was just a panic attack but I couldn’t help but freak out. Anyway, I got over it eventually and I went through the exam (which went well I think, I was anxious for nothing).

So after I got back home and decided to workout, now at this point I hadn’t eaten or had any significant amounts of fluid in about 20 hours, I’d been awake for around 36-40 hours but I wanted to work out anyway, so during the workout my heart rate was very, very high and I had a tightness in my chest, and towards the end during some curls I started feeling light headed, my HR became irregular and extremely fast (atrial fibrillation, this had never happened to me before) and I was like “shit, better go lie down”, the reason I didn’t check into a hospital was because if I did I’d have to come clean about what I’d done, and with my doctors that’s a last resort, if I’d had someone like you or a doctor that was open to monitoring me I wouldn’t been more comfortable with checking myself in. Anyway, I was in bed and my heart rate didn’t go down that much, during afib I believe it was well over two hundred, and then while in bed it was 120, but an hour in, while lying down, my heart started beating rapidly and irregularly again, I got up because I was like “that’s it, gotta check myself in”, I was nauseous, sweaty etc. So I got up and fell down, then got up again and sat down for a minute, and the heart rate went back to around 120BPM, still tachycardia, and my heart was beating HARD, like serious palpitations, I was almost sure I was going to die, so I sent out some texts to anyone who knew what I was doing telling them that it was no one’s fault but my own and for no one to blame themselves, that if anything bad happens to me I have few regrets etc. I lied in bed and kind of accepted the fact that this might be the end, but eventually after what seemed like an eternity the symptoms subsided, my heart rate is still elevated when I walk, but resting it’s no longer above 100bpm. Now I’ve decided I’m not going to use 200mg post cycle anymore, I’m just going to use what the doctors prescribe me regardless if I feel like shit or not, and I’m never using stimulants to help me study ever again. 200mg would probs get me to 900-1000ng/dl, and although I feel great up there, todays scare was too much.

Now, I’m sure it was synergy, the stims, the anxiety, the exercise, lack of food intake (and likely low blood sugar, the testosterone and previous brief use of nandrolone and oxandrolone, the lack of sleep, dehydration and stress), however I don’t want to risk something like this ever happening again, I’m going to be laying off exercise for a while too. I can’t rule out the risk of AAS induced heart damage given my bad luck previously, do I have dilated cardiomyopathy? Have I caused cardiac damage on a molecular level? Who knows, potentially for the first one and probably for the second one, unfortunately I won’t be able to find out, as I can’t go to a doctor and be all like “hey, I’ve used AAS”, which then goes back to my doctor giving me TRT, I get pulled off TRT and a whole new set of problems arise.

Anyway, today fucking sucked, if I stop posting or coming online just automatically assume something bad has happened to me. @physioLojik I don’t know you in person, therefore I don’t know whether you’d be concerned about this, probably not as you don’t know me in person, I’m just putting this out here because I feel like it’s important and I’m putting this out as a deterrent for anyone else who does stupid shit like this. I was aware of the potential side effects/ interactions of the two stimulants, I just figured “well it’ll be fine if it’s just once, and it’ll help me get a better ATAR which is worth it”. It’s strange the stupid and irresponsible things things some of us will do and justify accomplishing what we REALLY want, like getting into med school as an undergraduate. Anyway, to anyone reading this, judge away. Will I die soon? Potentially, I don’t know, it’d suck if I did that’s for sure. I’m not sure if I’ll ever be comfortable using non-prescription AAS again.

@anon10035199 Whether this event was a consequence related to my blast there’ll never be a way to tell, however I do know that 17y/olds shouldn’t be having serious arrythmias from events like the one told above, considering there’s tons of kids my age who use METHamphetamine, drink to excess multiple times a week and they aren’t having any current heart troubles.